A retrospective study of coagulation parametres in patients of pregnancy induced hypertension
Journal Title: Indian Journal of Pathology and Oncology - Year 2018, Vol 5, Issue 3
Abstract
Introduction Human pregnancy also known as gestation is the time between fertilization of ovum to delivery of a baby It is approcximately a process of 9 months during which new baby develops inside a womb Physiologically pregnancy is a hypercoagulative state Hypercoagulable state in pregnancy is a naturally occuring preventive response to prevent excess loss of blood during delivery It is essential to know the range of variations of the coagulation factors during normal pregnancy if any specific component has to be incriminated as a causative agent for the vascular disorder Preeclampsia is a serious and life threatening complication in pregnant women It is a pregnancy specific disorder which rates among one of the major causes of maternal and foetal morbidity and mortalityAims and Objectives To evaluate severity of eclampsia by estimating coagulation profile tests in pregnancy induced hypertensive patients To compare these biochemical parameters between the test group and control group To correlate the outcome of pregnancy with these biochemical parametersMaterials and Methods This retrospective study includes 120 females of uncomplicated pregnancy of age group 1635 years as a control group and 120 females of same age group with pregnancy with hypertension PIH attending obstetric outdoor patient department OPD of the institute in the year of 2015 Blood samples are withdrawn from all participants for biochemical markers of coagulation study that includes total platelet count PC prothrombin time PT and activated partial thromboplastin time APTTResults Among total 120 PIH participants 44 3667 cases were having mild gestational hypertension 11 917 cases were having severe gestational hypertension 34 2833 cases were having mild preeclampsia and 31 2583 cases were having severe preeclampsia The mean value of PT and APTT is found to be high in PIH cases as compared to control group participantsConclusion Parameters like total platelet count PC prothrombin time PT and activated partial thromboplastin time APTT can be used routinely as an early indicator for the assessment of PIH cases and also for detection of its severity It can also be used to monitor the progression of gestational hypertension to prevent serious complications like preeclampsia and eclampsia More number of preeclampsia cases are seen in underdeveloped and developing countries due to late diagnosis and inadequate antenatal servicesKeywords Eclampsia Platelet count Preeclampsia Pregnancy APTT PT
Authors and Affiliations
Akash C. Chhabra, Navinkumar R. Patel
Keywords
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- EP ID EP475910
- DOI 10.18231/2394-6792.2018.0079
- Views 59
- Downloads 0
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