A Retrospective Study of Patients with Recurrent or Refractory Testicular Germ Cell Tumors Treated with High-dose Chemotherapy and Autologous Peripheral-blood Stem-cell Transplantation Single-center Experience
Journal Title: Türkderm - Deri Hastalıkları ve Frengi Arşivi - Year 2019, Vol 18, Issue 4
Abstract
Objective: Patients with recurrent metastatic germ cell tumor (GCT) can be treated with second-line or even third-line regimens; 20-30% of testicular GCT (TGCT) relapse or become refractory after first-line therapy and optimal treatment for this group is not very well defined. Materials and Methods: We presented the analysis of the efficacy of high-dose chemotherapy and peripheral-blood stem-cell transplantation in patients treated between 2016 and 2019. Five patients with five autologous stem-cell transplantations (ASCT) were analyzed retrospectively. All patients were treated with bleomycin, etoposide, cisplatin as first-line therapy and paclitaxel, ifosfamide, cisplatin was given as salvage chemotherapy. Stem–cell collection was performed with granulocyte stimulating factor. ASCT was performed with carboplatin (700 mg/m2) and etoposide (750 mg/m2). The results were provided as median (min-max). Results: After ASCT, all patients were in complete remission (CR). The follow-up after ASCT was 12 months. At the 12-month follow-up, four patients were still alive and in CR, and only one patient died at 6th month after ASCT due to recurrence. Grade 2/4 toxicities were observed in five patients. Only one patient died due to complications of transplantation. Conclusion: Although the number of the patients in this study was limited, ASCT seemed to be a safe and effective treatment modality in recurrent refractory non-seminomatous TGCT, and treatment-related mortality was very low in this heavily pretreated group.
Authors and Affiliations
Şebnem İzmir Güner, Ekrem Güner
Keywords
Related Articles
- EP ID EP665783
- DOI 10.4274/uob.galenos.2019.1284
- Views 94
- Downloads 0
Topical tacrolimus for the treatment of acrodermatitis continua of Hallopeau: A case report and review of the literature
Acrodermatitis continua of Hallopeau (ACH) is a chronic and recurrent inflammatory disorder characterized by erythema and pustular lesions localized on the acral regions. Nail dystrophy, matrix destruction, anonychia, an...
The efficacy of adalimumab therapy in refractory hidradenitis suppurativa: Retrospective analysis
Background and Design: Hidradenitis suppurativa (HS) is a painful, chronic, inflammatory skin disease and there is no effective standard method for its treatment. The studies on the successful results of adalimumab in th...
Surgical correction of primary cicatricial alopecia: Experience with nine patients
Background and Design: Primary excision and hair transplantation are infrequently used to treat stable primary cicatricial alopecia (PCA). Follicular unit extraction (FUE) method has gained popularity in recent years. In...
Gougerot-Carteaud syndrome treated with acitretin: A case report
Gougerot-Carteaud syndrome (GCS) is a rarely seen dermatosis characterized by reticular and pigmented plaques with a tendency to merge with each other in areas such as the neck, upper body, and axilla in young adults. A...
Is hyaluronidase injection effective in treating tear trough hyaluronic acid filler deformity?
.