A REVIEW OF ANTIBIOTIC USED IN SUSPECTED EARLY-ONSET NEONATAL SEPSIS FROM MALAYSIAN PERSPECTIVE: WHICH ONES TO CHOOSE AND HOW LONG TO GIVE?
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2019, Vol 12, Issue 1
Abstract
Objective: Suspected early-onset sepsis is a common diagnosis among neonates which warrants admission to the neonatal intensive care unit. Prolonged empiric antibiotic is the biggest concern and treatment duration is still controversial. Antimicrobial stewardship (AMS) program promotes early antibiotic de-escalation to reduce unnecessary antibiotic exposure and its implementation in the intensive care setting seems to be feasible. The primary objective of this review was to compare the existing guidelines and review the literature regarding choice and duration of empiric antibiotic in managing suspected early-onset neonatal sepsis.Methods: Two Malaysian Ministry of Health guidelines were compared with guidelines from America (n=1), Australia (n=1), and United Kingdom (n=2). The literature search was conducted from January to June 2017 through open access journal and databases available at the author’s institution library (EBSCOHost, Ovid and Science Direct).Results: All guidelines recommended similar antibiotics range and suggested to review treatment at 36– 72 h post antibiotic exposure. A total of 113 abstracts and full articles were identified, and only 11 full-text articles published in English were related to the subject of interest. All studies show differences either in study design, choice of antibiotics, treatment duration or outcome measures; thus, a meta-analysis was not possible to be conducted.Conclusion: From this review, we found the potential to performed early empiric antibiotic de-escalation especially in clinically well-appearance neonates, and it is best to customize our guidelines based on local evidence which justify the need for more local research in this area.
Authors and Affiliations
Nazedah Ain Ibrahim, Mohd Makmor Bakry, Shareena Ishak, Noraida Mohamed Shah
Keywords
Related Articles
- EP ID EP607196
- DOI 10.22159/ajpcr.2019.v12i1.29489
- Views 108
- Downloads 0
EVALUATION OF DIURETIC ACTIVITY OF PICRIA FEL-TERRAE LOUR LEAVES EXTRACTS
Objective: The aims of this study was to evaluate the diuretic activity of different leaves extract of Picria fel-terrae using n-hexane, ethylacetate and ethanol as solvents. Methods: The diuretic activity of the extrac...
EFFECTIVENESS OF LOW-COST CUSTOMIZED SADDLE PILLOW ON PAIN IN POST-EPISIOTOMY PATIENTS
Objective: To examine the effectiveness of customized saddle pillow for pain in post-episiotomy patients and also to analyze the duration of sitting for breastfeeding and other functional activities following episiotomy....
A PHARMACOGNOSTICAL AND PHARMACOLOGICAL REVIEW ON BRYOPHYLLUM PINNATUM (PANPHUTI)
Bryophyllum pinnatum is usually known as Panphuti which belong to family Crassulaceae growing widely in tropical Africa, tropical America, India, China, and Australia. It is a perennial herb grows 3–5 feet tall, fleshy...
DIFFERENTIAL EXPRESSION ANALYSIS OF KRUPPEL LIKE FACTORS 6 AND ANTAGONISTIC EFFECT STUDY OF CINNAMIC ACID - AN IN SILICO APPROACH
Objective: Krüppel-like factor 6 (KLF6) is the significant member of a DNA binding proteins which mainly involved in the transcriptional regulation as well various promising cellular processes such as cell proliferation...
RELATED SUBSTANCE METHOD DEVELOPMENT AND VALIDATION OF LOXAPINE SUCCINATE IN CAPSULE DOSAGE FORM BY REVERSE PHASE HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY
Objective: The present study gives a simple, rapid, and accurate stability indicating reverse phase high-performance liquid chromatography method for the determination of loxapine succinate and its related substance (rel...