A Review on Analytical Methods for Determination of Guaifenesin Alone and In Combination with Other Drugs in Pharmaceutical Formulations
Journal Title: Saudi Journal of Medical and Pharmaceutical Sciences - Year 2017, Vol 3, Issue 3
Abstract
Abstract: Guaifenesin is an expectorant and it is use to treat cough and congestion caused by the common cold, bronchitis, and breathing illness. The drug is official in Indian Pharmacopoiea, British Pharmacopoeia, and United States Pharmacopoeias. This article reviews the different analytical methods available for detection of Guaifenesin alone and in combination from various pharmaceutical formulations. They are many analytical techniques have been reported for simultaneous estimation of Guaifenesin and its combined pharmaceutical dosage form but only fewer methods have been reported for estimation of Guaifenesin alone. Some of those techniques are UV spectrophotometry, high-performance liquid chromatography (HPLC), high-performance thin layer chromatography (HPTLC), liquid chromatography - mass spectrometry (LC-MS), gas chromatography (GC), and ultraperformance liquid chromatography (UPLC). Amongst, various analytical methods are available for the quantification of single and multicomponent dosage forms. Keywords: Guaifenesin, Spectrophotometry, Chromatography, Expectorant, Pharmaceutical formulations
Authors and Affiliations
Prayas Acharya, T Prasanth Kumar, Immanuel Agasteen, Sreerama Rajasekhar, G Neelima
Keywords
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