A Review on Hyphenated Separation Techniques Used in Pharmaceutical Analysis
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2016, Vol 11, Issue 6
Abstract
Hyphenated techniques combine chromatographic and spectral methods to exploit the advantage of both. Chromatography produces pure or nearly pure fractions of chemical components in a mixture.The development of the pharmaceuticals brought a revolution in human health. Pharmaceuticals would serve their intent only if they are free from impurities and are administered in an appropriate amount. To make drugs serve their purpose various chemical and instrumental methods were developed at regular intervals which are involved in the estimation of drugs.The review of hyphenated technique includes various techniques which are used nowadays for analysis. Chromatographic techniques GC,LCetc., are used for separation and spectroscopic techniques such as NMR,MS,IR used for identification purpose. Pharmaceuticals may develop impurities at various stages of their development, transportation and storage which makes the pharmaceutical risky to be administered thus they must be detected and quantitated. For thisanalytical instrumentation and methods play an important role. This review highlights the role of the analytical instrumentation and the analytical methods in assessing the quality of the drugs. The review highlights a variety of hyphenated analytical techniques applied in the analysis of pharmaceuticals.
Authors and Affiliations
Devi Thamizhanban1, TuljaGampa Rani2, Patlolla Pravalika2
Keywords
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- EP ID EP386759
- DOI 10.9790/3008-1106026574
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