A Review on Recall and Ban of Ranitidine: Facts & Theories
Journal Title: Advances in Clinical Toxicology - Year 2024, Vol 9, Issue 2
Abstract
The twentieth century witnessed the rise of peptic ulcers as a chronic illness affecting up to 10% of people worldwide. Initially thought to be caused solely by factors like stress and diet, the discovery of Helicobacter pylori bacteria by Robin Warren and Barry J. Marshall in 1982 revolutionized the understanding and treatment of peptic ulcers. This led to the development and widespread use of drugs like ranitidine, a histamine H2-receptor antagonist, which effectively reduced stomach acid production and provided relief from ulcer symptoms. However, recent concerns about ranitidine’s safety arose when elevated levels of the carcinogenic contaminant N-nitrosodimethylamine (NDMA) were found in some formulations. This prompted regulatory actions, including recalls, and raised questions about the long-term use of ranitidine and its potential health risks.
Authors and Affiliations
Borade SA* and Bade AA
Keywords
Related Articles
- EP ID EP754567
- DOI 10.23880/act-16000313
- Views 2
- Downloads 0
Hepatoprotective Activity of Hydroalcoholic Extract of Murraya Koeinigii Leaves against CCl4-Induced Hepatotoxicity in Rats
The objective of the present study was to evaluate hepatoprotective activity of hydroalcoholic extract of Murraya koenigii leaves (HAMK) in rats. Hepatic damage was induced by administration of carbontetra chloride (1 m...
Environmental Justice, Toxicology and Politics
The Earth and all its inhabitants, including humans, regardless of color, race, income level, or nationality, should be treated with respect as to the implementation and / or enforcement of environmental policies, laws o...
The Response of Fresh Water Fish Syndontisclarias Juveniles to Varied Zinc Sulphide Concentrations Obtained from the River Benueat Makurdi, Benue State Nigeria
Zinc is one of the heavy metals that is common in the Earth’s crust. This metal gets into the environment through manmade and natural ways. In this study, standard solutions of zinc sulphide were prepared and exposed to...
Environmental Contamination of Pesticides and its Toxic Effects as Endocrine Disruptors
The intensive use of pesticides in agriculture inevitably leads to the fact that the residues of these agrochemicals can be detected in water, air and soil. In general, these residues degrade slowly, which is why they ar...
The Toxic versus Therapeutic Interactions of Tyrosine Kinase Inhibitors and Radiation Therapy
Introduction: Progress in both the development of Tyrosine Kinase Inhibitors (TKIs) and modern radiation therapy (RT) have opened new horizons for the safe and effective treatments of cancer. Combination therapies of TK...