A REVIEW ON THE THERAPEUTIC POTENTIALS OF PARTHENOLIDE: A SESQUITERPENE LACTONE
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 2
Abstract
Medicinal plants have been widely employed in treating various diseases for centuries and are still a major resource and repository that can be further exploited for a variety of infectious and non-infectious ailments. The popularity of medicinal herbs has grown significantly in recent years despite a dearth of information regarding their modes of action and continuing concerns over their efficacy. Hence there is a necessity to study various plants meticulously with respect to their biological properties. Recent efforts to elucidate the mechanisms of action of several anti-inflammatory herbs have focused on a class of compounds, sesquiterpene lactones, which are believed to be the active components of these herbal medicines. At present, the pharmacokinetics of sesquiterpene lactones is not well known. Parthenolide is a major sesquiterpene lactone isolated from medical herbs Tanacetum parthenium (commonly known as feverfew) and from Magnolia grandiflora. Feverfew has been traditionally used as a herbal medicine for the treatment of fever, arthritis, and migraine in Asia and Europe for centuries. Hence, the present study discusses various biological properties of parthenolide and its mode of action which can be used in drug designing processes to maximize efficacy and minimize side-effects.
Authors and Affiliations
George Cijo , Naveen Kumar, Suresh P. K. , Ashok kumar
Keywords
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