Abstract

A non-communicable disease comprising various vascular diseases namely renal microvascular disease, cerebrovascular disease, and coronary vascular disease, has been a threatening public health problem today. The failure of preventive strategy is due to the lack of understanding the nature of the origin of vascular disease. In this regard, it is likely to take place at very early stage following the natural imbalance between the mechanism of vascular injury and repair resulting in an excessive production of vascular toxins, and an insufficiency of vascular repairing process, commonly occurring in an unhealthy person with inappropriately consuming of imbalanced diets, an inadequate physical activity in accordance with the national activity guidelines, and with mental and physical stress-a characteristic of self-insufficiency status. Such process of vascular disease develops spontaneously and continuously throughout life inducing a progressive ischemic state till target organ damage is well established. Recognition and treatment of the disease is usually late due to the lack of sensitive diagnostic marker available for early detection of the disease process, and fails to correct the ischemia as well as unable to restore the renal function. In contrast, a prevention of the development of vascular disease can be accomplished at the early stage of the occurrence of the disease under self-sufficiency condition.

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