A short Review on Stomach Specific Floating in-situ gel
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2012, Vol 1, Issue 3
Abstract
Oral drug delivery is a one of the simplest routes of delivery of drugs for systemic and in certain cases local effect. Liquid oral dosage forms are convenient to administer as compared to solid dosage forms but cannot achieve sustained effect due to less residential time in gastrointestinal tract. In-situ gel provides the best way to overcome problems of immediate release and short gastrointestinal residence of liquids. The in situ gel dosage form is a liquid before administration and after it comes in contact with gastric contents due to one or more mechanisms gets converted to gel which floats on gastric contents. This achieves increased residence as well as sustained release. This approach is useful for systemic as well as local effect of drugs administered. This review gives a short idea about floating oral in-situ gel formation and research done by various scientists on a number of drugs and polymers.
Authors and Affiliations
Kishor K. Bhalerao*| P. E. Society’s Modern College of Pharmacy, Nigdi, Pune-411 044 (Maharashtra), Meghana S. Kamble| P. E. Society’s Modern College of Pharmacy, Nigdi, Pune-411 044 (Maharashtra), Pravin P. Aute| P. E. Society’s Modern College of Pharmacy, Nigdi, Pune-411 044 (Maharashtra), Sandeep M. Dange| P. E. Society’s Modern College of Pharmacy, Nigdi, Pune-411 044 (Maharashtra), Rohini P. Chavan| P. E. Society’s Modern College of Pharmacy, Nigdi, Pune-411 044 (Maharashtra), Krunal K. Vaidya| P. E. Society’s Modern College of Pharmacy, Nigdi, Pune-411 044 (Maharashtra), Sanket B. Munot| P. E. Society’s Modern College of Pharmacy, Nigdi, Pune-411 044 (Maharashtra), Pravin D. Chaudhari| P. E. Society’s Modern College of Pharmacy, Nigdi, Pune-411 044 (Maharashtra)
Keywords
Related Articles
- EP ID EP1553
- DOI -
- Views 408
- Downloads 28
FORMULATION AND EVALUATION OF MATRIX TYPE TRANSDERMAL PATCHES OF ATORVASTATIN CALCIUM
In present work was designed to develop suitable transdermal matrix type of Atorvastatin calcium, using Hydroxy propyl methyl cellulose (HPMC) and ethyl cellulose (EC) with PEG 400, n-DB (as plasticizers) and propylene...
EFFECT OF MOMORDICA CHARANTIA L. SEEDS EXTRACT ON BIOPHYSICAL AND BIOCHEMICAL PARAMETERS OF WOUND IN EXPERIMENTALLY INDUCED DIABETES IN RATS
Momordica charantia Linn. seed extrat in the form of an ointment (20% w/w dried powder in simple ointment base) was evaluated for wound-healing potential in an excision wound model whereas the the seed extract given or...
Immunopharmacological activity of medicinal plants against Aristolochia bracteolate and Phallus impudicus
Introduction: Immunological attempt was made to determine the potential of seven important medicinally plants viz., Ficus benghalensis, Mangifera indica, Adhatoda vasica, Syzygium cumini, Terminalia arjuna, Ficus religio...
PREVALENCE OF HERPES SIMPLEX VIRUS IN CSF SPECIMENS OF NEONATES WITH ENCEPHALITIS BY USING REAL TIME PCR
Background: Herpes simplex virus (HSV) causes a spectrum of clinical manifestations in the central nervous system (CNS). Neonatal HSV infection following exposure to the virus at delivery produces severe disseminated in...
RELEVANCE OF EPIGENOMICS IN THE MANAGEMENT OF CANCER
The recognizable proof of all epigenetic adjustments involved in gene expression is the succeeding stage for an improved comprehension of human biology in both typical and obsessive states. This field is implied as Epig...