A spectroscopic study on Calf thymus DNA binding properties of nickel (II) complex with imidazole derivatives of 1,10-phenanthroline ligand
Journal Title: Iranian Chemical Communication - Year 2018, Vol 6, Issue 1
Abstract
In this study, a nickel (II) complex with 1,10-phenanthroline based ligand, [Ni(FIP)2](OAC)2 (1) with FIP = 2-(Furan-2-yl)-1H-Imidazole[4,5-f][1,10] phenanthroline as ligand was synthesized and characterized by spectroscopic methods and elemental analysis. The interaction of [Ni(FIP)2](OAC)2 (1) with calf-thymus DNA (ct-DNA) was studied by UV-vis absorption, fluorescence spectroscopies and viscosity measurements in 20 mM Tris/HCl buffer solution, pH 7.0 at 25 °C. The complex (1) interacts with ct-DNA with an intrinsic binding constant of 1.11 ×105 M-1. Furthermore, the thermodynamic studies suggested that the interaction processes were endothermic disfavored (ΔH >0) and entropy favored (ΔS >0). The viscosity studies showed no considerable increasing changes in the viscosity of ct-DNA with increasing of the complex (1) concentration. Therefore, the [Ni(FIP)2](OAC)2 complex bind to ct-DNA via hydrophobic interaction as the main forces acting during the binding processes and the mode of binding is groove binding which was illustrated by hyperchromism in the UV-vis absorption band of [Ni(FIP)2](OAC)2 (1) with addition of ct-DNA and the decreasing of ethidium bromide (EB)-ct-DNA complex fluorescence in the presence of different concentrations of [Ni(FIP)2](OAC)2 complex and the unchanged viscosity of ct-DNA.
Authors and Affiliations
Alireza Amini khouzani, Nasrin Sohrabi, Nahid Rasouli, Mahboube Eslami Moghadam
Keywords
Related Articles
- EP ID EP260546
- DOI -
- Views 115
- Downloads 0
An improved structure models to explain retention behavior of atmospheric nanoparticles
The quantitative structure-retention relationship (QSRR) of nanoparticles in roadside atmosphere against the comprehensive two-dimensional gas chromatography which was coupled to high-resolution time-of-flight mass spect...
Unexpected one pot pseudo four-component reaction for the synthesis of (10E)-N-benzylidene-2-phenylH-imidazo [1,2-a]pyridin-3-amine derivatives under solvent-free conditions
This work described an efficient Pseudo four-component synthesis of (10E)-N-benzylidene-2-phenylH-imidazo[1,2-a]pyridin-3-amine derivatives from 2-aminopyridin, malononitrile and arylaldehydes in the presence of NaOH und...
Synthesis and characterization of termini azobenzene dendrimer
Some organic molecules can be isomerized upon photoirradiation and when accompanied by a change in the visible absorption spectrum, it is called photochromism. Azobenzenes are important part of molecular machines and nan...
Isolation and structure elucidation of coumarin and cinamate derivatives from Lycium ruthenicum
Lycium species is a popular medicinal plant in the traditional Chinese medicine and Lycium ruthenicum is a native medicinal plant of Iran. Lycium genus has several biologically important properties too. Investigation of...
Effects of structure and number of Heteroatom on the π-π stacking interactions of benzene with N-substituted coronenes: A theoretical study
Stability of the π-π stacking interactions in the Ben||N-substituted-coronene complexes was studied using the computational quantum chemistry methods (where Ben is benzene and || denotes π-π stacking interaction, and N-s...