A Study of 120 Umbilical Cord Whole Blood Transfusions in 77 Patients with Different Clinical Conditions
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 4
Abstract
Background-After birth, placenta is normally discarded and has 80 ml to 150 ml whole human blood. Placental cord blood, because of its rich mix of fetal and adult hemoglobin, plasma with higher concentration of cytokines and growth factors along with high platelet and leukocyte count has the potential to be a safe alternative to adult human blood and is useful in transfusion dependent patients as well as in degenerative, autoimmune and geriatric conditions. It could be saved, stored and utilized in the goodness of the patients. Aims and Objectives Present study is aimed to establish the fact that Umbilical cord blood is safe for transfusion and a true alternative to adult human blood, furthermore its usefulness in different clinical conditions. Materials and Methods The present study was carried out from 1 st February 2015 to 31st August 2016 at a tertiary care centre. A total number of 150 umbilical cord blood units were collected and 120 fit units were transfused to 77 pre-registered patients. Follow up of the patients for three months was done to observe the outcome of transfusions. All data was collected, compiled and compared statistically by frequency distribution and percentage proportion. Results – In the study, mean blood volume in ml/unit was 80.75±13.06 SD. Average age of patients in years was 26.19±20.5SD. Out of 77 Patients, males were 46(59%) and Females were 31(41%). ABO group distribution of the patients was A:20, B:34, O:16 and AB:7. 120 Cord blood units transfused to following patients;Thallassemia32, Vitiligo30, hematopoietic malignancies15, Anemia14, Aplastic anemia12, geriatric Patients 09, sickle cell anemia 04, retinitis pigmentosa 02 and Idiopathic Thrombocytopenia 02. In transfusion dependent patients, hemoglobin was increased by 0.5-1 gm/dl, RBCs volume reduced by 10-20% and interval between two transfusions increased by 10±2 days. Re-pigmentation in Vitiligo, Improvement in vision field in retinitis pigmentosa, control of blood sugar in diabetes, and general improvement in geriatric patients was observed. Adverse event was reported in 02 (1.6%) transfusions. Conclusion- From our observations, we concluded that umbilical cord whole blood is a genuine alternative of adult human blood. It is helpful in correction of anemia in transfusion dependent patients, useful in neonatal transfusion and a hope for geriatric, autoimmune and degenerative disorders.
Authors and Affiliations
Dharmesh Chandra Sharma, Nidhi Agrawal, Jyoti Bindal, Poonam Woike, A. S. Tomar, Anita Arya
Keywords
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- EP ID EP593808
- DOI 10.9790/0853-1604040512.
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