A STUDY OF ANTICONVULSANT EFFECT OF FLUNARIZINE AND NIFEDIPINE IN COMPARISON WITH SODIUM VALPROATE ON MES AND PTZ MODELS OF EPILEPSY IN ALBINO RATS
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2015, Vol 2, Issue 13
Abstract
BACKGROUND: CA+2 ions are involved in initiation as well as spread of seizures. Hence current study was undertaken to evaluate the anticonvulsant effect of calcium channel blockers flunarizine, nifedipine and compare their efficacy with that of sodium valproate, the broad spectrum anticonvulsant in MES and PTZ induced seizures in albino rats. MATERIALS AND METHODS: Albino rats were treated with nifedipine 2.5mg/kg, 5mg/kg, flunarizine 7.5mg/kg,15mg/kg and sodium valproate 250mg/kg bodyweight intraperitoneally and the effects were observed in MES and PTZ models of epilepsy. The parameters observed in MES model was, duration of HLTE phase. Convulsive phase, and post ictal depressive phase. In PTZ model duration of seizure latency, duration of convulsion, and duration post ictal depression were observed. RESULTS: our study demonstrated that both calcium channel blockers afford protection against convulsions induced in both models, and flunarizine affords higher degree of protection than nifedipine, with its efficacy almost approaching that of sodium valproate. CONCLUSION: Flunarizine has significant, while nifedipine has moderate degree of anticonvulsant activity as compared to sodium valproate.
Authors and Affiliations
Umesh G. Wari, Suresh S. Kendri, Girish H. Vasanad
Keywords
Related Articles
- EP ID EP226762
- DOI 10.18410/jebmh/2015/275
- Views 78
- Downloads 0
URETERIC STRICTURES AN ANALYTICAL STUDY OF AETIOLOGY, PATHOLOGY AND MANAGEMENT
BACKGROUND Ureteric strictures are common diseases of India due to tuberculosis, instrumentation, congenital and other reasons. In this study we found that tuberculosis (27%) and instrumentation (27%) were the leading ca...
PROSPECTIVE STUDY OF UTERINE LEIOMYOMAS IN A TERTIARY CARE HOSPITAL
BACKGROUND: Fibroids are benign smooth muscle neoplasms that may occur singly, but more often are multiple. Uterine tumors are the most common and the leading cause of hysterectomy in women. METHODS: The present study is...
MINOR PHYSICAL ANOMALIES IN POSITIVE VERSUS NEGATIVE SYMPTOMS PATIENTS OF SCHIZOPHRENIA
BACKGROUND The term ‘Minor Physical Anomalies (MPAs)’ has been described by Jones (1988)78 as “unusual morphologic features that are of no serious medical or cosmetic consequences to the patient. The value of their diagn...
A STUDY ON THE COMPLICATIONS OF IMMEDIATE POST-PARTUM IUCD INSERTION
BACKGROUND: More than half of Indian women in the first year post-partum wish to use a family planning method, but only one fourth is utilizing any method. This study was done to assess the complications of immediate pos...
MODIFIED ALVARADO SCORING AS A DIAGNOSTIC TOOL IN ACUTE APPENDICITIS- A PROSPECTIVE STUDY
BACKGROUND Acute Appendicitis commonest community-acquired intra-abdominal infections. Acute appendicitis and its associated complications are significant source of morbidity and sometimes mortality. The Modified Alvarad...