A STUDY OF ATYPICAL MANIFESTATIONS IN PULMONARY TUBERCULOSIS CORRELATING WITH CD4 COUNT IN HIV SEROPOSITIVE PATIENTS
Journal Title: International Journal of Microbiology Research - Year 2016, Vol 8, Issue 2
Abstract
Background: HIV infection is major risk factor for progression to active tuberculosis. The typical symptoms, upper lobe disease and sputum positive for AFB are seen in patients with CD4 T cell count above 200 cells/cu µl. Patients with impaired immunity usually have atypical clinical, radiographic features, extra pulmonary disease and disseminated disease. So, diagnosis requires thorough work up. Methodology: The impact of CD4 count on various manifestations of 50 HIV seropositive patients with tuberculosis was studied. Results: Majority of patients were in the age group of 30-40 yrs. 58% were males and 42% females. The most common form was pulmonary TB (76%) followed by Pleural effusion (26%). X-ray findings showed bilateral infiltrations in 38% cases; Mid and lower zone infiltration in 26% cases and upper zone in 14%. Majority were Sputum -ve (68%), only 32% were sputum +ve. Mean CD4 count being 146.6±88; Mean CD4 in sputum positive TB was 254.8±77 and sputum negative TB was 97.2±33.8 and extra pulmonary TB was 142.3±55.3. All patients with upper zone lesions in chest x -ray had CD4 > 200 cells/µl and 84.6% of patients with mid and lower zone lesions had CD4 count 50-200. Conclusion: CD4 counts correlated well with clinical profile of TB, which showed that when CD4 counts were < 200 cells/µl , sputum negative pulmonary TB and disseminated pulmonary TB were more common. Chest x-ray were atypical in the form of lower zone involvement and more of infiltrative lesion.
Authors and Affiliations
N. B. SWAROOPRANI, S. RAJKUMAR
Keywords
Related Articles
- EP ID EP169964
- DOI -
- Views 109
- Downloads 0
MANAGEMENT OF PEARL MILLET SMUT PATHOGEN (Tolyposporium penicillariae) THROUGH PLANT EXTRACTS
Pearl millet (Pennisetum glaucum L. R. Br.) is an important cereal crop in India, which forms stable diet for nearly ten percent Indian population. Smut caused by Tolyposporium penicillariae Bref. is the most common and...
PROBIOTICS AND PREBIOTICS
Probiotics and prebiotics are a special class of food products as their application in wellness of human beings is well established. Probiotics are living microorganisms that are taken as dietary supplements while prebio...
COMPARISON AND PCR CONFIRMATION OF ENTERIC PROTOZOAL ISOLATES IN AIDS PATIENTS- OPTIMIZING DIAGNOSTIC APPROACH IN DIFFERENT RESOURCE SETTINGS
Opportunistic infections in AIDS patients are a harbinger of death. In this study presence of enteric protozoa (Cryptosporidium parvum, Cyclospora cayetanensis, Enterocytozoon bienuesi) as causative agents of diarrhea in...
AEROBIC VAGINITIS – TRUTH AND MYTH
Background: Vagina is a microbiological museum where most types of aerobic and anaerobic organisms are present as normal commensals but when there is imbalance in the flora, the individual experiences abnormal vaginal di...
ESTIMATION OF POPULATION AND EVALUATION OF RHIZOSPHERE MYCOFLORA AND FLUORESCENT PSEUDOMONADS AGAINST Rhizoctonia solani UNDER IN VITRO CONDITION
Tomato crop is attacked by several soil borne fungal pathogens among which Rhizoctonia solani is the most important soil borne pathogen causing symptoms of damping off, crown rot and root rot. To provide bio-efficacy aga...