A Study of Comparative Efficacy and Safety of Two Different Drug Regimen in the Management of Dermatophyte Infection.
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2019, Vol 4, Issue 2
Abstract
Background: Superficial fungal infections of the skin, hair and nail are a major cause of morbidity in the world, particularly in the tropics, where heat and humidity provide the ideal conditions for the growth of fungi that cause skin infections. Methods: A hospital based comparative prospective study included 400 patients of dermatophytoses having Tinea cruris and Tinea corporis attending the outpatient department of Dermatology, Venereology and Leprosy in PBM hospital Bikaner. Patients randomly divided into 2 groups -i)Group A received Tablet Fluconazole 150 mg per week plus Tablet Griseofulvin 10mg per kg bodyweight daily in two divided doses, ii)Group B received Tablet Fluconazole 150 mg per week. Treatment to all groups was given for a period of 4 weeks. The data were analyzed on EPI-Info-6 Software. Results: There was no statistically significant difference in both groups was observed at 1st, 2nd & 3rd weeks and statistically significant difference in both groups was observed at 4th & 8th weeks follow-up. Conclusion: The combination of Fluconazole and Griseofulvin is a bettar treatment option to treat tinea cruris and corporis as compared to mono therapy with Fluconazole.
Authors and Affiliations
R. D. Mehta
Keywords
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