A study of efficacy of double dose versus standard dose hepatitis b vaccine in HIV-infected children
Journal Title: MedPulse -International Medical Journal - Year 2019, Vol 6, Issue 1
Abstract
Objective: To compare the efficacy of double dose (20 μg) with standard dose (10 μg) of hepatitis B vaccine in HIV-infected children. Methods: Unvaccinated HIV-infected children were randomized to receive 3 doses of double dose (N=27) or standard dose (N=28) of recombinant Hepatitis B vaccine. Anti-HBs antibody titres were measured 3 mo after the lastdose. An antibody titre≥10 mIU/mL 12 weeks after the third dose was considered as serporotection. Result: Seroprotection was achieved by 17 (60.7%) children in standard dose group against 20 (74%) in the double dose group [RR (95%CI) 0.8 (0.17-1.7); P=0.29].CD4 count < 500 cells/mm3 was significantly associated with lower rates of seroprotection. Conclusion: Double dose of hepatitis B vaccine does not seem to provide any advantage when compared to standard dose in HIV-infected children.
Authors and Affiliations
Mani Shankar, Ashok Kumar
Keywords
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- DOI 10.26611/1004616
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