A STUDY OF HAEMATOLOGICAL MANIFESTATIONS IN HUMAN IMMUNE DEFICIENCY VIRUS POSITIVE PATIENTS BEFORE AND AFTER ANTIRETROVIRAL THERAPY
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2019, Vol 6, Issue 21
Abstract
BACKGROUND HIV infection is a multisystem disease and haematological abnormalities are among the most common complications of HIV. HIV associated haematological abnormalities seem to be dependent on the level of virus replication, as these abnormalities are severe in late stage AIDS patients with high viremia. These abnormalities reflect the underlying immune status and may be prevented or corrected by use of highly active antiretroviral therapy (HAART). METHODS One hundred HIV positive patients, symptomatic as well asymptomatic, diagnosed by enzyme-linked immunosorbent assay (ELISA) method according to the National AIDS Control Organization (NACO) guidelines were included. Complete haematological profile was recorded. The haematological parameters of each patient were evaluated at 0-, 6- and 12-months following initiation of HAART. RESULTS Out of 100 patients included in this study, 58% (58) were males and 42% (42) were females with the sex ratio of 1.38:1. The haematological profiles were presented as mean ± standard deviation. A p value of 0.05 was considered statistically significant. There was a significant improvement in CD4 cells, haemoglobin, red cell count and haematocrit and platelet counts after 6 months and 12 months of therapy. Improvement in total count, absolute neutrophil count and absolute lymphocyte count was observed after 12 months of HAART. CONCLUSIONS This study shows that there was improvement in all parameters in these patients and also in the stage of disease when they were followed for one year. So, regular follow up and compliance of patient is of utmost importance in checking the progress of disease as well as ensuring better quality of life. It can be concluded that in people living with HIV/AIDS, HAART is useful for modifying the mortality and morbidity.
Authors and Affiliations
Madhu Balla, Vijay Kumar
Keywords
Related Articles
- EP ID EP667279
- DOI 10.18410/jebmh/2019/310
- Views 104
- Downloads 0
EFFECT OF HIGH & LOW INTENSITIES OF AEROBIC EXERCISE ON PHYSICAL FITNESS INDEX
BACKGROUND: Aerobic exercise reduces body fat and improves weight control, increases HDL&Vo2 max. Also improves PFI (physical fitness index) which is defined as ability to carry out daily tasks with vigour and alertness...
ANALYSIS OF LOCKED COMPRESSION PLATING IN OSTEOPOROTIC FRACTURESPROSPECTIVE STUDY
BACKGROUND Fractures in osteoporotic bones pose challenges to the treating orthopedists due to the complex problems in fixation of osteoporotic bones.1,2,3,4 Failure of treatment usually results due to less bone purchase...
OCULAR DISORDERS IN CHILDREN WITH DEVELOPMENTAL DELAY
BACKGROUND In India, an estimated 1.5-2.5% children below 2 years of age are developmentally delayed. A higher incidence of ocular disability is seen in these children, refractive errors and strabismus being most common....
A FRONTAL BONE SWELLING GUIDED TO REACH THE DIAGNOSIS OF RENAL CELL CARCINOMA
PRESENTATION OF CASE A 59 year male presented to Urology Outpatient Department (OPD) with a painless forehead swelling. He was operated for the same swelling two times within last three months by an orthopaedic surgeon i...
STUDY OF COMPLICATIONS OF COLLES FRACTURE TO FIND OUT THE TRUE INCIDENCE OF EXTENSOR POLLICIS LONGUS TENDON RUPTURE AND CARPAL TUNNEL SYNDROME IN INDIAN POPULATION
Colles‟ fracture is confined to adult and usually is seen in women over the age of fifty who have fallen on the outstretched hand. EPL tendon is the most common extensor tendon to rupture after colles‟ fracture. To our b...