A study of micronutrient status in multidrug resistant tuberculosis patients at a tertiary care center
Journal Title: IP Indian Journal of Immunology and Respiratory Medicine - Year 2018, Vol 3, Issue 3
Abstract
Introduction Micronutrients deficiency is supposed to impair the overall immune function and causes increased resistance to infection Such a relationship exists even in tuberculosis A major threat is multidrug resistant tuberculosis MDRTB In India few studies are available to discuss about risk factors and serum zinc and selenium status in MDRTBMaterial and Methods A case control study of 25 diagnosed MDRTB patients from Damian foundation and 25 healthy controls from Narayan Medical College were recruited after laboratory tests chest Xray and clinical history 5 ml of blood collected and serum zinc and selenium levels were assessed for both groups and correlated with demographic factors duration of treatment and BMIResults The results indicate that the MDRTB patients have altered profile of the serum zinc and serum selenium in their sera and this could be more due to the active disease causing oxidative stress which depletes the micronutrients In this study the mean serum zinc levels were 7908 142 gdL and 911 152gdL in case and control groups respectively Serum selenium levels were 562 111 gdL and 652 42gdL in case and control groups respectively In both the groups micronutrient levels showed statistical significantConclusions The risk factors in our study such as lower level of serum zinc was one of the concern for the development of MDRTB and an attempt to minimize them might contribute to control the upward slope of MDRTBKeywords Immune status Serum zinc Serum selenium TB
Authors and Affiliations
GP Vignan Kumar, M. Jahnavi, Rajesh Reddy, Subhash B. Reddy, B. Raviteja
Keywords
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- EP ID EP490598
- DOI 10.18231/2581-4222.2018.0026
- Views 89
- Downloads 0
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