A Study of Outcome Analysis of Treatment in 100 Cases of New Sputum Positive Pulmonary Tuberculosis Under RNTCP
Journal Title: Gujarat Medical Journal - Year 2019, Vol 74, Issue 1
Abstract
Introduction: The United Nation's Sustainable Development Goals (SDGs) along with the World Health Organization's end TB strategy has made global targets for “To End the Global Epidemic of Tuberculosis (TB).” RNTCP launched Fix Dose Combination (FDC) for treatment of patients of drug-sensitive TB. FDC drugs contain the four main molecules - Rifampicin, Isoniazid, Pyrazinamide and Ethambutol—in one pill. RNTCP mandates to take sputum sample for GeneXpert of every Sputum smear positive, so it helps to make early diagnosis. Objectives: To know the treatment outcomes and to find the correlation between the radiological and bacteriological aspects in cases of new sputum positive pulmonary tuberculosis on treatment of Fixed drug combination under RNTCP. Method: In this prospective study, we considered 100 new sputum smear-positive pulmonary TB patients aged 11 years diagnosed in our TB unit. Before starting the treatment Sputum AFB by Fluorescent stain was examined. The follow up was done at the end of Second month (End of Intensive Phase) and Sixth months (End of treatment). And the data was analyzed using appropriate statistical tests. P-value less than 0.05 is considered as significant. Result: The 89.65% successful treatment outcome of all new sputum positive TB patients observed in our study achieved the target i.e. 90% of RNTCP for the 12th 5 years plan (2012–2017). Poor adherence with treatment and malnutrition were significantly associated with non conversion (P = 0.03). Patients with TB and diabetes mellitus were found to be highly significantly associated (P = 0.01) with sputum non conversion at end of Intensive Phase.
Authors and Affiliations
Dharit Shah, Pratik Patel, Vishakha Kapadia, Savita Jindal, Sanjay Tripathi, Sanskruti Patel
Keywords
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