A STUDY ON BLOOD BILIRUBIN LEVELS IN TERTIARY CARE CENTRE OF KUMAUN REGION (UTTARAKHAND) INDIA.
Journal Title: Journal of Biomedical and Pharmaceutical Research - Year 2013, Vol 2, Issue 5
Abstract
Jaundice occurs in most newborn infants. Most jaundice is benign, but because of the potential toxicity of bilirubin, newborn infants must be monitored to identify those who might develop severe hyperbilirubinemia and, in rare cases, acute bilirubin encephalopathy or kernicterus. Some babies are at an increased risk for developing jaundice: Babies who have Rh or ABO incompatibility with their mothers, Babies with a lot of bruising to their scalp or face during delivery, Premature babies , Babies of diabetic mothers , sick newborns who may not feed well in the first few days of life. The concept of prediction of jaundice offers an attractive option to pick up babies at risk of neonatal hyperbilirubinemia. Physical examination is not a reliable measure of serum bilirubin. Under these circumstances it would be desirable to be able to predict the risk of jaundice, in order to implement early treatment and thereby minimize the risk of bilirubin dependent brain damage. Neonatal Hyperbilirubinemia has been defined as the bilirubin levels > 12.9 mg/dl in term babies and 15 mg/dl in preterm babies. Neonatal jaundice is visible manifestation in skin and sclera of elevated serum concentrations of bilirubin and this usually occurs in neonates if serum bilirubin level is >5 mg/dl. Most adults are jaundiced when total serum bilirubin (TSB) levels exceed 2.0 mg/dL.The study was conducted in 171 newborns in neonatal unit, Department of Pediatrics, Dr. Sushila Tiwari Government Hospital and Government medical college, Haldwani Distict Nainital (Uttarakhand) from September 2009 – November 2010. Serum bilirubin estimation was done in the Central laboratory (Bio chemistry deptt), Dr. Sushila Tiwari Government Hospital & Government medical college, Haldwani Distict Nainital (Uttarakhand). Bilirubin estimation was done by Diazo method in which a detergent is used to accelerate the reaction is used. High bilirubin levels on 1st, 2nd and 7th day of life i.e; 8.95 mg/dl, 8.56 mg/dl, 24.7mg/dl respectively were due to Rh and ABO incompatibility (30.4%). In view of 30.4% neonates developing hyperbilirubinaemia on first and second day of life and 64 neonates (69.6%) having peak serum bilirubin levels of 13.39mg/dl on 3rd day of life. although peak serum bilirubin levels are seen on fifth day of life.
Authors and Affiliations
Veena Prasad*| Professor, Department of Pediatrics, Government medical college, Haldwani, Distt-Nainital (Uttarakhand), India., Nutan Singh| Associate Professor, Department of Pediatrics, Government medical college, Haldwani, Distt-Nainital (Uttarakhand), India.
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