A Study on Effect of Omega 3 Fatty Acids in Hypertriglyceridemia
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 3
Abstract
Introduction: Hyperlipidaemia is a major modifiable risk factor in primary and secondary prevention of coronary artery disease. Studies have shown that serum triglycerides were an independent risk factor for CAD events, irrespective of serum levels of high density lipoprotein cholesterol (HDL-C) or low density lipoprotein cholesterol (LDL-C). Many epidemiological and interventional studies suggest that omega 3 polyunsaturated fatty acids confer a protective role against atherosclerotic disease and having a greater impact in reducing serum triglyceride levels. Aims: The aim of our study was to see the effect of omega 3 fatty acids on serum triglycerides in patients of hypertriglyceridemia. Effect on various variables of lipid profile was observed simultaneously. Material And Methods: A total of 100 patients (46 males and 54 females) of hypertriglyceridemia (>150 mg/dl) were included. They received capsules of eicosapentaenoic acid with docosahexaenoic acid in a dosage of 3g/day for 8 weeks. To see the efficacy of the drug, lipid profile was measured at 0 week, after 4 weeks and 8 weeks of the treatment. The data from our present study was systematically collected, compiled and statistically analysed using software IBM SPSS 22.0 to draw relevant conclusions. Study Design: The study done was a non-randomised, prospective therapeutic study. It consisted of a treatment period of 8 weeks for all the patients, after their written/informed consent and approval from the Institutional thesis ethical committee. Results: Serum Triglycerides reduction (237.71±45.77 vs. 188.44±40.67mg/dl; p<0.001) and VLDL reduction (47.54±9.15 vs. 37.69±8.13 mg/dl; p<0.001), was highly significant after 8 weeks of treatment. HDL-cholesterol levels increased highly significantly (37.40±3.96 vs. 39.14±3.40 mg/dl; p<0.001).Total cholesterol also decreased highly significantly (221.71±25.22 vs. 213.97±22.31 mg/dl; p<0.001) but no significant change was found in serum LDL (p>0.05). The percentage reduction was highest in serum triglycerides and VLDL levels by 20.95% followed by a percentage rise of 4.90% in serum HDL levels. Conclusion: Omega 3 fatty acids intervention have a positive role in improving lipid profile but with a greatest impact in reducing serum triglycerides which is an independent risk factor of CAD
Authors and Affiliations
Priya Bharati
Keywords
Related Articles
- EP ID EP277799
- DOI -
- Views 100
- Downloads 0
Carcinoma in situ Cervix Extension into Endometrium: An Unusual Case Report.
Invasive squamous cell carcinoma is the most common gynecological malignancy in India. Precursor lesion cervical carcinoma in situ with superficial extension to the endometrium without involving myometrium is very uncomm...
A Survey on Awareness about Pharmacovigilance among Community Pharmacists in Resource Limited Settings of India
Over the past four decades there has been a trend for pharmacy practice to move away from its original focus on medicine supply towards a more inclusive focus on patient care. Due to the introduction of a large number of...
Role of Immunohistochemistry in Diagnosis of Undifferentiated Malignant Tumours
Background: Immunohistochemistry provides a true identitiy for undifferentiated tumours. The accurate typing of malignant and benign tumours are important for prognostic and therapeutic purposes. Aim: The present study i...
A Prospective Study of Evaluation of Different Methods of Preoperative Hair Removal And Their Relationship To Postoperative Wound Infection
INTRODUCTION - Wound site infections are a major source of postoperative illness, accounting for approximately a quarter of all nosocomial infections. The prevention of surgical site infections encompasses meticulous ope...
Prevalence of Phlebitis and Comparison of the Effectiveness of Topical Ichthammol Glycerin and Heparinoid Application on Phlebitis among Patients on Peripheral Intravenous Therapy
Aim: The aim of this study was to determine the prevalence of phlebitis and compare the effectiveness of topical ichthammol glycerin and heparinoid application on phlebitis among patients receiving intravenous therapy. B...