A Study on Efficacy and Safety of Silodosin in Geriatric Patients with Benign Prostatic Hyperplasia
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 1
Abstract
Introduction: Benign prostatic hyperplasia(BPH) is a very common condition among elderly men causing significant symptoms with urination and results in bladder outlet obstruction. Silodosin is a recently developed selective α1A-adrenoreceptor antagonist for the medical treatment of BPH. This study is to evaluate the efficacy and safety of silodosin 8mg in geriatric patients with BPH. Materials And Methods: A prospective observational study was done at K.S.Hegde Medical Academy, Mangalore, India on 53 patients with BPH during August 2014 to march 2016. These patients were aged ≥ 50 years, with international prostate symptom score(IPSS) of ≥12 and having a peak urinary flow rate (PFR) <15 ml/sec on uroflowmetry. Patients were treated with silodosin 8mg once daily and were followed up. We assessed the changes in IPSS,PFR and adverse effects of the drug at baseline, 1 month and 3 months after treatment. Results: The mean age of subjects was 63.32±6.6. Their mean IPSS scores were 25.06±2.87,18.91±3.92, 16.19±4.9at baseline, 1month and 3 months respectively with significant improvement(p<0.0001). There was also a significant increase in the peak urinary flow rate(PFR) (p<0.0001). The only adverse effect encountered was retrograde ejaculation. In three out of 5 patients this problem subsided without any intervention. Conclusions: Silodosin is an effective and well tolerated drug producing significant improvement in IPSS and PFR with fewer cardiovascular side effects in this frail population. Therefore silodosin can be used as a first line agent in BPH and continuation of this drug will avoid a surgical intervention.
Authors and Affiliations
Dr. Chilukala Sai Praneeth, Dr. Rajeev T. P2, Dr. Shubhakar Bhandary, Dr. Chaitanya Reddy
Keywords
Related Articles
- EP ID EP588899
- DOI 10.9790/0853-1601040611
- Views 109
- Downloads 0
Prevalence of Urinary Tract Infection (UTI) and Concomitant Urinary Schistosomiasis among Primary School Children in Remo North Local Government, Ogun State, Nigeria.
The urinary tract infection (UTI) which affects any part of the urinary tract is one of the most common paediatric infections that may cause permanent kidney damage. The most common causative organisms are bowel flora. S...
Effect of Denture Cleansers on Color Stability of Different Acrylic Resin Materials
Objective: The objective of this investigation was to assess the effects of different denture cleansers and distilled water on color stability of self-polymerized (SP) and heat-polymerized (HP) acrylic denture base mater...
Primary Carcinosarcoma of the Uterine Cervix: Case Report and Review of the Literature
Carcinosarcoma of the uterine cervix are very rare tumors, constituting only 0.005% of all cervical malignancies (fewer than 70 cases of cervical carcinosarcoma have been reported in the English literature). It usually p...
A Clinico-Radiological Study to Determine the Predictive Factors for Difficult Laparoscopic Cholecystectomy
BACKGROUND: Pre-operative prediction of a difficult laparoscopic cholecystectomy(LC) can help the patient as well as the surgeon to prepare better for the intra-operative risk of LC and to reduce the risk of conversion t...
Restorative periodontal interrelationship
The interrelationship of restorative dentistry and periodontics is ever changing. Various guidelines are set for performing restorations that are compatible to periodontium. In order to achieve superior restorative resul...