A Study on Hemoglobin Electrophoresis Profile in Patients with Moderate to Severe Anemia
Journal Title: International Journal of Contemporary Medical Research - Year 2018, Vol 5, Issue 3
Abstract
Introduction: Hemoglobinopathy patients can benefit temporarily with nutritional supplementation and blood transfusions but long term outcome can be better if specific diagnosis is made and specific therapy or precautions are undertaken. The aim of the study was to determine frequency of hemoglobin disorders in patients presenting with moderate to severe anaemia using hemoglobin electrophoresis. Material and Methods: Indoor patients from departments of internal medicine and paediatrics with moderate to severe anemia (without other chronic illness), in a hospital in rural area, were included in the study. Hemoglobin electrophoresis was performed on them to evaluate for presence of hemoglobin disorders. WHO reference range was taken for anemia classification. Results: Out of 335 samples included in the study, 144 (43%) were found to have hemoglobinopathies with sickle-beta thalassemia being the most common occurrence followed by beta-thalassemia carrier and sickle cell disorder. Betathalassemia major was less common. Out of 144 patients with hemoglobinopathies, 86 were males and 58 females. Mean hemoglobin levels at presentation were also calculated and beta-thalassemia presented with the lowest mean hemoglobin (3.7 g/dl). Conclusion: Recent statistics (NFHS-4) suggest that half of the children and females and about one-fourth of males in India are suffering from some degree of anemia. These figures can have serious economic as well as health related implications, especially for a developing nation like India. When properly managed, the outcome and quality of life of patients with hemoglobin disorders can be improved and since, a significant percentage of patients in our study were found to have hemoglobinopathies of varying severity, it would be advisable to perform investigations to determine specific cause of anemia especially in rural areas where supportive management stays the mainstay of treatment in most scenarios.
Authors and Affiliations
Bushra Khanam, Sudhir Maurya, Prakhar Gupta, Shainila Shaikh
Keywords
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