A Study on Mean Platelet Volume (MPV) in Patient with Type 2 Diabetes Mellitus and its Relation with Microvascular Complications and Hba1c Level
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2018, Vol 6, Issue 1
Abstract
Vascular complications are one of the important causes of morbidity and mortality in type 2 diabetes mellitus. Platelets have a major role in development of these vascular complications. Platelet activity is found to be increased in cases of diabetes. Platelet index, MPV is an indicator of platelet activity and size. The aim of our study is to find out the role of platelet activity in diabetes and its relation to vascular complications by measuring the mean platelet volume in diabetics and comparing with that of non diabetics and its correlation with HbA1c, FBS, PPBS, LDL, HDL, TG, TC and duration of diabetes. An institutional study was conducted comprising of 210 diabetics study group and 210 non diabetic age and sex matched control group. The study group was divided into two groups, with and without vascular complications. The counts were done in anticoagulated blood using automated hematology analyser (Sysmex XT 2000i). The mean platelet volume was found to be significantly increased in patients with complications than those without complications and non diabetics. Also there was a significant correlation between the MPV and Hba1c, FBS, PPBS and duration of diabetes. Our study suggested a significant association between mean platelet volume and development of vascular complications in diabetic patients. So the mean platelet volume can be used as a better prognostic marker for assessing development of vascular complications in type2 diabetes mellitus.
Authors and Affiliations
Debiprasad Mishra, Jayanti Nayak, Himadri Sekhar Paul
Keywords
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