Abstract

Introduction: Cytokines are responsible for many of the symptoms and signs of the infection, particularly fever and malaise. Plasma concentrations of cytokines are elevated in both vivax and falciparum malaria. Methodology: All these patients were subjected to slide test for thick and thin smear as well as immunochromatographic test, ROT, Pan malaria or Falci check. Blood investigations like hemoglobin level, total leukocyte count, differential count and serum electrolyte and also renal function tests, liver function tests, random blood sugar were done in all cases. Results: Serum bilirubin was raised in 33 cases, but only14 cases had serum bilirubin > 3 mg/dL. maximum total bilirubin noted was 18.4 mg/dl. Out of 14 cases, 9 cases had conjugated hyperbilirubinemia and 5 cases had unconjugated hyperbilirubinemia Conclusion: Hepatic dysfunction in acute P.falciparum malaria ranged from mild elevation of liver enzymes to acute hepatitis.

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