A STUDY ON PROTECTIVE ROLE OF PRUNUS AMYGDALUS ON ALCOHOL INDUCED RETROGRADE AMNESIA
Journal Title: Indo American Journal of Pharmaceutical Research - Year 2017, Vol 7, Issue
Abstract
Abstract Ethanol and Prunus amygdalus (PA) are most widely used in the world. PA is a popular nourishing food, along with its nutritional values it also possess medicinal values like anti-stress, anti oxidant, immunostimulant, lipid lowering and laxative. Ethanol- induced retrograde amnesia was investigated using Morries Water Maze, Elevated plus Maze. Anxiety and locomotion was assessed using open field test. Rats received Prunus amygdalus suspension (150mg/kg, 300mg/kg, and 600mg/kg., oral) for 7 days, and Alcohol (3g/kg, 20%, i.p) in 6th day of the treatment. The next day they were accessible for Behavioral assessment. Rats receiving Alcohol shows significant reduction in escape latency (MWM), Time spent in open arm (EPM), Number of ambulations and rearing (OFT) and increase in Immobility time (FST). The current study evidenced learning and memory impairment, anxiety, and depression symptoms in rats characterized by behavioral impairment, increased oxidative stress, apoptosis, following exposure to ethanol. PA suspension helps in recovery of disrupted memory after ethanol inducing alterations in brain, ultimately, improved the memory (spatial and learning), anxiety and depression
Authors and Affiliations
Komati. Anusha*1, Preethi Chavan1, Jyothi Vadthya1, G. Bhavana1, Jabbarlal Naik2 Korra, Suresh Naik2
Keywords
Related Articles
- EP ID EP330702
- DOI -
- Views 101
- Downloads 0
BIOSYNTHESIS OF SILVER NANOPARTICLES AND CHARACTERIZATION
Abstract In current science, nanotechnology has been thriving at a tremendous rate in all aspect of Science and Technology. It deals with between 1 to100 nm sizes of nanoparticles in at least one dimension and involves i...
A STUDY TO ASSESS AND EVALUATE THE PRESCRIBING PATTERN OF ANTI- HYPERTENSIVE DRUGS IN A TERITARY CARE TEACHING HOSPITAL
Abstract Objective: The objectives of the study are to assess and evaluate the prescribing patterns of antihypertensive drugs in patients of a tertiary care teaching hospital,to compare the prescribing patterns of antihy...
FORMULATION AND EVALUATION OF FLOATING TABLET OF ESOMEPRAZOLE MAGNESIUM DIHYDRATE
Abstract Floating drug delivery system is the class of gastro retentive drug delivery systems. It is also called as Hydrodynamically balanced system. These are the low density systems they have the sufficient buoyancy to...
A PHARMACOLOGICAL PROMISE TOWARDS CELL CYCLE TARGET INHIBITION IN ANTICANCER DRUG DISCOVERY OF ULVAN ISOLATED FROM Ulva lactuca(L).
Abstract Objective: To prescreen the in vivo antiproliferative activity of the marine green alga Ulva lactuca Family Ulvaceae using the eukaryotic model organism Dictyostelium discoideum. Method: In the present study to...
VALIDATION OF A FORCED DEGRADATION UPLC METHOD FOR ESTIMATION OF BECLOMETHASONE DIPROPIONATE IN RESPULES DOSAGE FORM
Abstract Respules are the drugs in aqueous suspension form contained and packed in respiratory ampules, they are administered through inhalation by a device called nebulizer. The purpose of the study is to validate an UP...