A study on role of lipid peroxidation in diabetic patients in Thiruvarur District
Journal Title: International Archives of Integrated Medicine - Year 2018, Vol 5, Issue 12
Abstract
Introduction: Insulin affects many sites of mammalian lipid metabolism. It stimulates synthesis of fatty acid in liver adipose tissue and in the intestine. The insulin has also been reported to increase the cholesterol synthesis. The activity of lipoprotein lipase in white adipose is also increased. From this point of view, the assessment of various lipid fractions and lipid peroxide in the cases of Diabetes Mellitus may be of some help in the prognosis of patients and in preventing the possibilities of complications or secondary disorders. Aim of the study: To study the level of lipid peroxide in IDDM and NIDDM. To find out the correlation between Lipid peroxide and Lipid profile in both types of diabetes mellitus Materials and methods: Participants of the study group were selected from the outpatient's population of the Department of Medicine, Government Thiruvarur Medical College, Thiruvarur. 100 patients were selected for this study. Out of which 50 patients belong to NIDDM and 50 to IDDM group. 50 persons served as a healthy control. Results: There was a very good positive correlation between MDA and Cholesterol, TGL, LDL, VLDL in both NIDDM and IDDM cases. There was a negative correlation between MDA and HDL in NIDDM and IDDM cases. Conclusion: In the diabetes mellitus abnormally increased levels of lipid, lipoprotein and lipid peroxides in plasma may be due to the abnormal lipid metabolism. The maximum increase in lipid peroxide was found in a group of diabetes mellitus with complication. Elevated levels of lipid peroxide in diabetes mellitus may be due to the alteration of function of erythrocytes membrane. This inhibits the activity of superoxide dismutase enzyme leading to accumulation of superoxide radicals which cause the maximum lipid peroxidation and tissue damage in diabetes.
Authors and Affiliations
S. Sumathi, M. Ramadevi
Keywords
Related Articles
- EP ID EP425362
- DOI -
- Views 86
- Downloads 0
A study on periampullary diverticula – 6 years ERCP experience from a referral centre
Introduction: Periampullary diverticula (PAD) are mucosal outpouchings commonly situated on the medial aspect of second part of duodenum; usually within 2-3 cm of the ampulla of vater. PAD are usually asymptomatic incid...
Diagnostic utility of bone marrow aspiration in pancytopenia
Back ground: Pancytopenia is a common haematological finding in clinical practice. It is a striking feature of many serious and life-threatening illnesses, ranging from simple drug-induced bone marrow hypoplasia, megalob...
Cholecystectomies – A 1.5 year histopathological study
Background: The gallbladder is a surgically important organ of the body which may be affected by a variety of pathological processes, which are often, under appreciated. It has a wide spectrum of diseases ranging from co...
Assessment of awareness about HIV/AIDS in slum areas of Jodhpur city
Background: Human immunodeficiency virus (HIV) infection, the disease, whose mode of transmission is known and is largely preventable, but due to lack of knowledge and practices in general population causes its continuou...
Evaluation of gastric carcinomas with high resolution transabdominal sonography
Introduction: Assessment of the stomach is not commonly included in routine scanning protocol of upper abdominal ultrasound (USG). Aim: To evaluate the efficacy of high-resolution trans abdominal sonography in the eval...