A Study on the Antihypertensive Activity of MuktaVati (Ayurvedic Preparation) In Deoxycorticosterone acetate (DOCA) salt Induced Hypertension in Rats
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2014, Vol 2, Issue 3
Abstract
Mukta vati, an ayurvedic formulation is being routinely used to treat cardiovascular ailments like hypertension. However, so far its antihypertensive effect has not been validated in any animal model of hypertension. Therefore, the present study was performed to evaluate the antihypertensive effect of Mukta vati in Deoxycorticosterone acetate (DOCA) salt induced hypertension in rats. Hypertension was induced in male SD rats by administration of DOCA (10mg/rat,s.c) every alternate day and drinking water was replaced with 1% NaCl solution. The animals were kept for 6 weeks. The effects of Mukta vati (10mg/kg,p.o.) on hemodynamic parameters like systolic BP (SBP), diastolic BP(DBP), mean arterial pressure (MAP) and heart rate(HR), cardiac hypertrophy and oxidative stress (MDA andGSH levels) were studied. Preventive treatment with Mukta vati (10mg/kg,p.o.) for 6 weeks resulted in a significant reduction in SBP, DBP and MAP as compared to hypertensive group. However, there was no significant change in HR and cardiac hypertrophy parameters between the groups. Further, Mukta vati blunted hypertension induced oxidative stress as evident by the suppression of MDA level and upregulation of GSH levels.Our study corroborate the clinical observations that Mukta vati possess antihypertensive property and this property may be due to its anti oxidative action.
Authors and Affiliations
Sandeep Kumar Singh, Shahnawaz Ali Bhat, Kashif Hanif, MD. Imtiyaz Ahmad
Keywords
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