A Study to Correlate Elevated Creatinine Phosphokinase with Snake Bite and Acute Kidney Injury
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2019, Vol 18, Issue 1
Abstract
CONTEXT Hemotoxic snake bite is associated with acute kidney injury in around two thirds of cases. Thisstudy is toestablish therelation betweenelevated CPK values with acute kidney injuryand reversibility with alkaline diuresisin snakebite patients of GovernmentRajajiHospital, Madurai. AIMOFTHESTUDY To establish the correlation between creatinine phosphokinase with hemotoxic snakebite and acute kidney injury. To find out the benefit of sodium bicarbonate infusion in preventing creatinine elevation in such cases. SETTINGSANDDESIGN Prospective Cross sectional study MATERIALSANDMETHODS STUDY POPULATION: Patients with history of snake bite who fulfill the inclusion and exclusion criteria getting admitted in General Medicine wards of GOVT RAJAJI HOSPITAL, MADURAI, during the period of JANUARY 2016 TO JUNE 2016. STATISTICALANALYSIS Mean, standard deviation RESULTS The CPK values tend to correlate with the incidence of acute kidney injury and it can be prevented with soda bicarbonate infusion. CONCLUSIONS: This study correlates one of the factors in the prevention of AKI, but there are more than 10 mechanims attributed to the cause of renal failure in snake bite patients. So this intervention may be in addition to the other treatment with IVF, anti-venom, antibiotics and prevention of dehydration. The CPK values tend to correlate with the incidence of renal failure and it can be prevented with soda bicarbonate infusion. Other factors like NGAL levels were not measured to asses for the incidence of renal failure. So all these is to be considered in treating a patient with hemotoxic snake bite with elevated CPK values.
Authors and Affiliations
Kirthika K, Muralidharan Kandan, Victor Theophilus Prem Kumar
Keywords
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