A Topical Cream Containing Niacinamide 4% and Gluconolactone 14% Modifies the Local C. Acnes Population in Patients with almost no or Mild Facial Acne
Journal Title: Journal of Medical Science And clinical Research - Year 2018, Vol 6, Issue 3
Abstract
Background: C. acnes is involved in acne. Aim: To assess the evolution of C. acnes phylotypes,the antimicrobial activity, the risk for inducing antibiotic resistance emergence and the clinical efficacy of a cream containing niacinamide and gluconolactone. Methods: Prospective, open-label, non-comparative study performed in 21 adult patients with almost no or mild facial acne according to the GEA score. The main evaluation criterion was the genomic analysis of C. acnes phylotypes, using standard methods and clinical assessments made at baseline and Day56. Adverse events were reported throughout the study. Results: At baseline, the mean age was 23.5±5.5 years, 85.7% of the patients were female, main C. acnes phylotype was IA1 (71.4%). A C. acnes strain, resistant to clindamycin and erythromycin, potentially due to a mutation at position A2059G, was observed in two patients. The mean number of inflammatory lesions was 13.1±3.6 and the number of open or closed come dones was 20.2±5.4. At Day 56, a shift to a different C. acnes phylotype was observed in eight patients; in seven patients phylotypes remained unchanged. C. granulosum was still present in one patient, while no resistance or intermediate sensitivity was observed anymore. In one patient, RNA mutation 16S was absent, despite an intermediate susceptibility to tetracycline. The cream caused no antibiotic resistance emergence. Inflammatory and non-inflammatory lesion count and global severity had significantly improved from baseline; safety was excellent. Conclusion: The tested cream improves acne by modifying C. acnes phylotypes, thus changing the C. acnes population, without causing antibiotic resistance emergence.
Authors and Affiliations
Brigitte Dréno
Keywords
Related Articles
- EP ID EP508079
- DOI -
- Views 81
- Downloads 0
Inter-Proximal Space Management Using Indirect Ceramic Veneers
Teeth spacing defined as a dental anomaly characterized by interdental spaces and lack of contact points between the teeth, the etiology of spacing in dentition may be hereditary, acquired or functional. Using the approp...
A Hallmark of Progressive Diagnosis: Robinow Syndrome Identified By Clinical and Radiological Examination
Robinow syndrome also known as ‘fetal facies’ is a rare inherited disorder characterized by short stature due to mesomelic shortening of limbs, distinctive craniofacial, skeletal and genital abnormalities. It can have bo...
Clinical Utility of 10% Dextrose Solution as Analgesic after DPT Vaccination and it Comparison with Direct Breastfeeding
Objective: To compare analgesic effect of 10% dextrose solution with direct breast feeding, and placebo after DPT vaccination to 6week- 3month old infants. Participants and study Design: Infants coming for their DPT vacc...
A Study of Hepatic Involvement in HIV Positive Patients
Human immunodeficiency virus is probably the only pathogen with diverse sites of affection in human body. Not a single organ system in particular is immune to its effects. Effects are caused either directly by the virus...
Cytochemical Analysis of Immature Cells - Use As a Diagnostic & Prognostic Tool for Leukemia
Aims & Objectives: Our study aims to evaluate the role of cytochemical staining as a simple and cheaper method to confirm the diagnosis and prognosis of leukemia and its classification. Material & Methods: Fifty eight pa...