A tubular polycaprolactone/hyaluronic acid scaffolds for nasal cartilage tissue engineering
Journal Title: Engineering of Biomaterials / Inżynieria Biomateriałów - Year 2017, Vol 20, Issue 141
Abstract
In this preliminary study, 3D nanofibrous porous scaffolds in the form of spiral tubes for future application as nasal cartilages implants were fabricated by combining polycaprolactone electrospun fibers with drug modified hyaluronic acid gel. It is expected that the spiral form of the scaffold with open geometries, large surface area, and distance between the scaffold walls will be helpful for improving future cell penetration into the scaffolds, nutrient transport and metabolic waste removal, which are otherwise limited in conventional electrospun tissue-engineered scaffolds. The tubular scaffolds structure, its porosity and fibers’ diameter were assessed via scanning electron microscopy, and biological properties of the scaffolds were evaluated in an in vitro study using Simulated Body Fluid (SBF). SEM results showed that apatite formed within a short period on tubular scaffolds after its immersion in SBF, demonstrating high in vitro bioactivity of the scaffolds.
Authors and Affiliations
S. Jatteau, A. Kurowska, M. Ziąbka, I. Rajzer
Keywords
Related Articles
- EP ID EP538710
- DOI -
- Views 38
- Downloads 0
Effect of polylactide modification with β-TCP and lecithin on the properties of the material as a substrate for osteoblasts
Polylactide (PLLA) containing β-TCP is biodegradable composite and an attractive biomaterial for bone tissue engineering, however, hydrophobicity of PLLA based composites is major limitation for their use as scaffolds fo...
Wytrzymałość zmęczeniowa wielofunkcyjnej resorbowalnej płytki kompozytowej w symulowanych warunkach biologicznych
Artykuł jest kolejną częścią prezentującą wyniki badań mechanicznych wielofunkcyjnych resorbowalnych płytek zespalających. Testy dotyczyły wyznaczenia wytrzymałości zmęczeniowej płytek zespalających w warunkach symulując...
Tribological properties of resorbable polylactide-based biomaterials
The objective of this study was the observation and evaluation of tribological characteristics and behavior of biocomposites with polymer matrix under different friction conditions. Three types of polylactide composites...
Genotoxicity of antibacterial bioglasses obtained by sol-gel method for Salmonella typhimurium
Periodontal disease causes problems in dentistry. Surgical intervention with appropriate biomaterials for tissue regeneration is necessary in advanced stages of the disease. Therefore, the aim of this study was to determ...
Fabrication and physicochemical properties of pectin/chitosan scaffolds
Scaffolds from chitosan and its combinations with other polymers are widely used for tissue engineering application. This is due to the favourable biological properties of chitosan such as antimicrobial activity, biocomp...