A tubular polycaprolactone/hyaluronic acid scaffolds for nasal cartilage tissue engineering
Journal Title: Engineering of Biomaterials / Inżynieria Biomateriałów - Year 2017, Vol 20, Issue 141
Abstract
In this preliminary study, 3D nanofibrous porous scaffolds in the form of spiral tubes for future application as nasal cartilages implants were fabricated by combining polycaprolactone electrospun fibers with drug modified hyaluronic acid gel. It is expected that the spiral form of the scaffold with open geometries, large surface area, and distance between the scaffold walls will be helpful for improving future cell penetration into the scaffolds, nutrient transport and metabolic waste removal, which are otherwise limited in conventional electrospun tissue-engineered scaffolds. The tubular scaffolds structure, its porosity and fibers’ diameter were assessed via scanning electron microscopy, and biological properties of the scaffolds were evaluated in an in vitro study using Simulated Body Fluid (SBF). SEM results showed that apatite formed within a short period on tubular scaffolds after its immersion in SBF, demonstrating high in vitro bioactivity of the scaffolds.
Authors and Affiliations
S. Jatteau, A. Kurowska, M. Ziąbka, I. Rajzer
Keywords
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