A WEB-BASED RESOURCE FOR STRUCTURAL INFORMATION ON eIF5A AND ITS RELATED PROTEINS: NEW POTENTIAL THERAPEUTIC TARGETS IN MANY HUMAN DISORDERS
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2014, Vol 6, Issue 9
Abstract
Objective: There is a considerable therapeutic interest in eIF5A as a potential target for drug development through inhibition of hypusination. In this regards, protein structural information is fundamental. Herein, we reported the developing of a web-based system, called eIF5ADB, which compiles all protein structural data on eIF5A and its related proteins.Methods: The eIF5ADB database was implemented as a MySQL relational database, using PHP scripting language. Web interfaces were developed using HTML, CSS and JavaScript. The data were collected from PDB, UniProt and Entrez databases. These data were filtered appropriately using specialized literature.Results: The database provides three modules that allow to search, acquisition of contents and access to statistical data, besides direct links to matching to external databases.Conclusion: The platform developed here is very useful for researchers interested in this content and can be accessed at http: //www. gurupi. uft. edu. br/btoxdb/eif5adb.Â
Authors and Affiliations
Luiz Carlos Bertucci Barbosa, Leonardo Alves Dos Santos, Juliana De Souza Ferreira, Kelvinson Fernandes Viana, Alex Sander Rodrigues Cangussu, Raimundo Wagner De Souza Aguiar
Keywords
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