A work on synthesis & characterization of Piperidine-4-carbohydrazide derivatives with its antimicrobial evaluation of pharmaceutical interest.
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2016, Vol 5, Issue 3
Abstract
A series of piperidine-4-carboxylic acid methyl ester coupled with N-phthaloyl amino acids derivatives were synthesized, characterized and their antimicrobial properties were evaluated. These compounds were synthesized with dicyclohexylcarbodimide coupling of piperidine-4-carboxylic acid methyl ester with N-phthaloyl amino acids with N, N'-dicyclohexylcarbodiimide followed by ring opening reaction with cyclopropylamine and reaction of ester with hydrazine hydrate to obtain final compound characterized using IR, 1H and 13C-NMR and mass spectroscopy. The synthesized compounds were screened for their in vitro antimicrobial activity against S. aurous, E. coli, P. aeruginosa, S. typhimurium, F. oxysporum and A. alternate. Some of these compounds exhibited moderate to good activity, where as some were inactive
Authors and Affiliations
Paresh Shende
Keywords
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