Aberrant expression of CK8 in leukoplakia and oral squamous cell carcinoma: an immunohistochemistry study
Journal Title: Pathology Update: Tropical Journal of Pathology and Microbiology - Year 2017, Vol 3, Issue 2
Abstract
Introduction: In India, oral cavity cancer contributes to significant morbidity and mortality. Since only few of premalignant lesions turn into cancer and routine histopathology has limited prognostic value, therefore we need to devise methods to ascertain premalignant lesions with high potential for conversion to malignancy, appropriate management and early diagnosis of cancers. Cytokeratin K8 (CK8) may be used as surrogate markers in oral premalignant lesion and cancers, so we conducted the present study with an aim to evaluate & compare expression of CK8 in normal oral mucosa, leukoplakia as well as Oral squamous cell carcinoma (OSCC). Material and Methods: The present study included 107 pathological specimens of histologically proven cases of OSCC (n=19), leukoplakia (n=77) and benign lesions (n=10). All the cases were subjected to immunohistochemistry to check the expression of CK8 antibodies. Correlation was evaluated statistically by Chi-square test. Result: Increased expression of CK8 was seen in OSCC and leukoplakia with dysplasia. No immunoreactivity was seen in benign oral mucosa. Expression of CK8 was significantly correlated with dysplasia and cancer. Conclusion: CK8 can be used as marker of sequential premalignant changes in oral cancers.
Authors and Affiliations
Pooja Jaiswal, Siddhartha Shanker Sinha, Yogesh Kumar Yadav, Nausheen Sanaullah Khan, Mayank Kumar Singh, Ratna Saxena
Keywords
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- EP ID EP263800
- DOI 10.17511/jopm.2017.i2.24
- Views 112
- Downloads 0
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