Abstracts of the 20th Biennal Meeting of the ISN Satellite Symposium "MolecularBasis for Signal Transduction in Neurodegeneration and Neuroregeneration".
Journal Title: Pharmacological Reports - Year 2005, Vol 57, Issue 3
Abstract
Authors and Affiliations
Benzylpenicillin inhibits the renal excretion of acyclovir by OAT1 and OAT3.
Background: Acyclovir is acyclic guanosine derivative. Benzylpenicillin (PCG) is a β-lactam antibiotic. The purpose of this study was to investigate the pharmacokinetic drug-drug interaction (DDI) between PCG and acyclov...
Glial degeneration as a model of depression.
Major depression (MD) is a common and disabling disorder but knowledge of its pathophysiology is still incomplete. In the last years, degenerations or dysfunctions of glial cells, especially astrocytes, have been postula...
Therapeutic efficacy of naringin on cyclosporine (A) induced nephrotoxicity in rats: involvement of hemeoxygenase-1.
Background: Clinically, chronic nephrotoxicity may lead to renal functional impairment and progress to end stage renal failure. The renoprotective effect of a flavonoid naringin (NG) against cyclosporine A (CsA)-induced...
Are the endothelial mechanisms of ACE-ls already established?
The endothelial mechanism of ACE-Is action is multifaceted. On the one hand, by inhibiting ACE, ACE-Is diminish Ang II synthesis, one of the best known active peptides. On the other hand, they modify synthesis and releas...
Endothelial nitric oxide synthase (eNOS) in platelets: how is it regulated and what is it doing there?
Platelets express the endothelial form of the nitric oxide synthase (eNOS) and generate NO. However, in contrast to eNOS in endothelial cells, eNOS in platelets is largely Ca(2+)-independent and the activity is regulated...