Professor Stanisław Wolfarth, Ph.D., M.D. (1933-2007)

Frequency of common MDR1 gene variants in a Polish population.

P-glycoprotein (P-gp) is a transmembrane transporter playing an important role in drug efflux. There is growing evidence that P-gp activity may be related to haplotypes of MDR1 gene. In the current study, the frequencies...

Potential role of G protein-coupled receptor (GPCR) heterodimerization in neuropsychiatric disorders: a focus on depression.

G protein-coupled receptors (GPCRs) represent the largest family of membrane proteins in the human genome and are the target of approximately half of all therapeutic drugs. For many years, GPCRs were thought to exist and...

Are anti-inflammatory properties of lipoic acid associated with the formation of hydrogen sulfide?

Lipoic acid (LA) was shown to possess anti-inflammatory properties. In this study, we present evidence supporting the hypothesis that the anti-inflammatory properties of LA are associated with the formation of hydrogen s...

Pregabalin antinociception and its interaction with tramadol in acute model of pain.

Background: The aim of present study was to investigate the antinociceptive effect of pregabalin and tramadol either alone and or in combination on acute model of pain. Methods: The antinociceptive effect of intraperiton...