Accidentally discovered Portal Vein Thrombosis before Splenectomy due to Hypersplenism - The role of Thrombogenic Genes Polymorphisms
Journal Title: Archives of Hepatitis Research - Year 2017, Vol 3, Issue 1
Abstract
Portal vein thrombosis in patients with liver cirrhosis may be due neoplastic growth invading portal vein or due to non-neoplastic causes. The indications for treating PVT in cirrhotic individuals are difficult to be established but at least are of great benefit in acute PVT. Investigating the cause of portal vein thrombosis in cirrhotic patient prepared for splenectomy including virology and immune markers, AFP, triphasic CT. Factor V Leiden mutation and prothrombin gene 20210. The case showed non-neoplastic portal vein thrombosis due to portal pyemia with underlying prothrombin gene 20210 polymorphism. The early initiation of anticoagulation after the diagnosis of acute PVT may be the only predictive factor for complete PV recanalization with preservation of liver function.
Authors and Affiliations
Hanafy Amr Shaaban
Keywords
Related Articles
- EP ID EP559403
- DOI 10.17352/ahr.000015
- Views 54
- Downloads 0
Sarcoidosis-Lymphoma Syndrome presenting by severe Cholestatic Hepatitis
Severe cholestatic hepatitis is an uncommon presentation of either sarcoidosis or Hodgkin lymphoma. Sarcoidosis lymphoma syndrome is a rare disorder with sarcoidosis heralding the onset of lymphoma. Here we report a case...
Current Trends of Combination Therapy in Chronic Hepatitis B Management in China
In the past decade, five oral nucleos(t)ide analogs and two formulations of pegylated interferon alpha have been approved for the treatment of chronic hepatitis B (CHB). Due to low personal income and inadequate health c...
Constipation during Entecavir treatment in Chronic Hepatitis B patients: Two Cases Reports
Entecavir (ETV) is an oral nucleoside analog inhibitor of hepatitis B virus (HBV) DNA polymerase, which is widely used in patients with chronic hepatitis B (CHB). Despite the excellent safety data of this agent, the adve...
Liver Specific Serum Micro RNA122 as a Prognostic Marker in Egyptian Patients with Liver Cirrhosis
Introduction: Recent research has shown that microRNAs (miRNA) are emerging as important regulators of cellular differentiation. The miR-122 accounts for approximately 70% of all miRNAs in the liver so its presence in th...
Occupational Hazard (Hepatitis B & C)
Hepatitis B and C are considered as an important health hazard among health care workers (HCWs). These blood borne infections can be transmitted either from HCW to a patient or vice-versa. Both viruses are known to cause...