Accuracy of Various Creatinine Based Prediction Equations For Estimating Glomerular Filtration Rate in Prospective Donors in Comparison to DTPA Renogram.
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 3
Abstract
Objectives: A noninvasive and accurate estimation of GFR is one of the holy grails of renal function evaluation. We analysed accuracy of CKD Epidemiology Collaboration (CKD-EPI), Modification of Diet in Renal Disease (MDRD) and Mayo Clinic Quadratic (MCQ) equations to estimate GFR with reference to a standard GFR obtained by DTPA renal scan. Methods: Between June 2011 and June 2013, healthy adults underwent DTPA renal clearance studies as part of a routine work-up for potential kidney donation. 70 subjects had sufficient data to estimate GFR- including age, gender, Creatinine (Cr){based on average of 2 values obtained 2 weeks apart performed at the same hospital lab}. Results: Mean GFR obtained by DTPA, CKD-EPI, MDRD and MCQ were 93.4±13.4, 86.94±14.8, 83.0±17.6 and 104.5±10.27ml/min/1.73m2 respectively. All equations correlated well with DTPA-GFR (p< 0.01). The bias and mean absolute difference in ml/min per 1.73 m2 between calculated and measured GFR for CKD-EPI, MDRD, MCQ were -6.57 and 11.03, -10.45 and 14.75, +11.1 and 14.13 respectively. Percentage of values within 30% and 50% of predicted in each equations were - CKD-EPI: 71.4%; 91.4%, MDRD: 51.4%; 81.4%, MCQ: 57.1%; 81.4%. Conclusion: CKD-EPI had least bias and was more accurate within 30 and 50% of the measured GFR even though it frequently under estimated measured GFR. MCQ equation (developed for patients with preserved renal function) had least bias in subset of measured GFR>90ml/min. In potential donors, these equations may not be sufficient for estimating GFR. Further studies are needed to derive prediction equations in Indians with normal renal function.
Authors and Affiliations
Dr Dineshan KM, Dr Aditya Shenoy, Dr Felix Cardoza
Keywords
Related Articles
- EP ID EP592488
- DOI 10.9790/0853-1603020106
- Views 79
- Downloads 0
“A Case Report of a Patient presented With Upper Respiratory Tract Infection and Diagnosed with IgA Nephropathy”
.
Survival Outcome and Its Predictors for Treated Patients with Glioblastoma Multiforme-A Single Centre Retrospective Study
Background: Glioblastoma multiforme is the most aggressive form of primary brain tumour with a median survival 1 year. Aim: To assess the survival outcome and predictive factors for theglioblastoma multiforme patients wh...
Management of Borderline Ovarian Tumour in A Pregnant Woman: A Case Report
Borderline ovarian tumors (BOTs) are neoplasms with benign and malignant characteristics, affecting young women in childbearing age. Finding incidental adnexal mass in pregnancy is more common with the use of ultrasound,...
Surgical outcomes of Modified supine vs Prone position in Percutaneous Nephrolithotomy
Aim: To compare the surgical outcomes of PCNLs performed using our modified supine position with those performed in the standard prone position Materials and Methods: 60 patients undergoing Percutaneous nephrolithotomy,...
Knowledge and awareness about dental implants as replacement of missing teeth among a small population in Anantnag
Aim The aim of the study was to assess the awareness of the patients regarding dental implants as an option for tooth replacement including knowledge about it and standpoint towards it amongst a small population in Anant...