Acid-Base Status of Patients with Diabetic Ketoacidosis and Ketonuria: Bosnia and Herzegovina Experience - - - Acido-bazni status bolesnika sa dijabetičnom ketoacidozom i ketonurijom: bosanskohercegovačko iskustvo
Journal Title: Acta Facultatis Medicae Naissensis - Year 2018, Vol 35, Issue 2
Abstract
The aim of this study was to analyze the values of biochemical parameters in patients with diabetic ketoacidosis and ketonuria. In this prospective comparative study conducted at the Clinical Center of the University of Sarajevo, hundred patients of both genders with diabetes mellitus were enrolled. Newly diagnosed diabetic patients with complications like acute ketoacidosis (n = 50) and ketonuria (n = 50) were included in this study and compared. The values of biochemical parameters in these patients were analyzed. We found that mean values of pH, base excess, hydrogencarbonate, sodium, glucose, urea and creatinine concentrations in patients with ketoacidosis were significantly different compared to patients with ketonuria. The values of potassium and calcium serum concentrations were not significantly different. Also, values of pH, base excess, as well as concentrations of hydrogencarbonate, sodium, potassium, calcium, glucose, urea and creatinine were not significantly different between male and female patients with diabetic ketoacidosis. In patients with diabetic ketonuria we found a correlation between admission glucose concentration and acid-base balance. - - - Cilj ove studije bio je da analiziramo vrednosti biohemijskih parametara kod bolesnika sa ketoacidozom i ketonurijom. U ovoj prospektivnoj komparativnoj studiji koja je provedena u Kliničkom centru Univerziteta u Sarajevu, uključeno je sto bolesnika oba pola sa dijabetesom melitusom. Uključeni su novodijagnosticirani bolesnici koji imaju dijabetes melitus sa komplikacijama poput ketoacidoze i ketonurije. Analizirane su vrednosti biohe-mijskih parametara kod ovih bolesnika. Utvrdili smo da su srednje vrednosti pH, baznog ekscesa, koncentracije hidrogenkarbonata, natrijuma, glukoze, uree i kreatinina kod bolesnika sa ketoacidozom signifikantno različite u odnosu na bolesnike sa ketonurijom. Za vrednosti koncentracija serumskog kalijuma i kalcijuma nije pokazana signifikantna različitost. Takođe, vrednosti pH, baznog ekscesa kao i koncentracije hidrogenkarbonata, natrijuma, kalijuma, kalcijuma, glukoze, uree i kreatinina nisu bile značajno različite kod muških i ženskih bolesnika sa ketoacidozom. Kod bolesnika sa dijabetičnom ketonurijom utvrdili smo pozitivnu korelaciju između početne vrednosti glukoze i acido-baznog statusa. Povećane vrednosti glukoze vode povećanju baznog ekscesa.
Authors and Affiliations
Edhem Hasković, Azra Bureković, Adnan Husić, Muhamed Fočak, Erna Islamagić
Keywords
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- EP ID EP349396
- DOI 10.2478/afmnai-2018-0015
- Views 84
- Downloads 0
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