Action of Melatonin on Severe Acute Liver Failure in Rats
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2017, Vol 12, Issue 3
Abstract
Severe acute liver failure (ALF) manifests itself as a rare syndrome, with multiple etiologies for similar clinical conditions. Melatonin (MLT) is a lipophilic indolamine that is synthesized in the pineal gland from serotonin. This study was designed to evaluate hepatic changes resulting from the thioacetamide-induced ALF model, as well as the effects of MLT treatment in male Wistar rats (n = 56) in 24- and 48-h experiments. The results indicate a hepatoprotective effect of MLT, with no difference between the studied times, and increased animal survival.
Authors and Affiliations
Jeferson de Oliveira Salvi1,, Elizângela Gonçalves Schemitt, Josieli Raskopf Colares2 ,, Renata Minuzzo Hartmann, Cláudio Augusto Marroni, Norma Anair Possa Marroni2,
Keywords
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- EP ID EP389244
- DOI 10.9790/3008-1203036275
- Views 97
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