ACTIVITY OF DIZOCILIPINE AND ITS COMBINATIONS WITH DANTROLENE AND LISURIDE ON THE LD50 PERIOD IN MICE WITH EXPERIMENTAL TETANUS
Journal Title: European Journal of Biomedical and Pharmaceutical Sciences - Year 2018, Vol 5, Issue 1
Abstract
Tetanus intoxication is a result of combined tetanus toxin binding in the organism: centrally in the spinal cord at the level of inhibitory synapses and peripherally at the level of the neuromuscular junction and muscle cell. Although acute intoxication is dominated by the central action of tetanus toxin, it is considered that, for the purpose of successful implementation of therapy, peripheral activity of the tetanus toxin should be also antagonized. Experimental tetanus was induced by intramuscular application of tetanus toxin. Application of substances on mice in experimental groups was performed after the occurrence of local tetanus in right leg, approximately 24 hours after administration of tetanus toxin. In this research, we attempted to normalize disorders caused by tetanus toxin using dizocilipine maleate (at doses of 0.01; 0.1; 1.0 and 2.0 mg/kg b.w.), alone and in combination with dantrolene (at dose of 2.0 mg/kg) and lisuride (at dose of 50.0 μg/kg) on the LD50 period in mice with experimental tetanus in the trial. Through our research, we found that dizocilipine had the best effect at a dose of 0.1 mg/kg b.w. Additionally, combination of dizocilipine and lizuride had no effect on the LD50 period, as compared to the control group.
Authors and Affiliations
Dr. Muhamed Katica
Keywords
Related Articles
- EP ID EP635002
- DOI -
- Views 149
- Downloads 0
ASSESSMENT OF LIVER ENZYMES LEVELS AMONG SUDANESE THYROID DYSFUNCTION PATIENTS
Background: Thyroid hormones exert their effect on all tissue and modulate the rate of metabolic activity. Alterations in thyroid function can affect the various organ system of body and perturb measures like AST, ALT, a...
OVERVIEW OF HEPATITIS B SURFACE ANTIGEN INCIDENCE AMONG PREGNANT WOMEN IN KING HUSSEIN MEDICAL CENTRE AND PRINCE HASHEM HOSPITAL
Objective: To determine the prevalence of hepatitis B surface antigen among pregnant women presenting to antenatal care clinic in Prince Hashem Hospital in Zarqa city and King Hussein Medical Centre (KHMC) in Amman, Jord...
CUTANEOUS MANIFESTATIONS IN HIV INFECTION: A CLINICOPATHOLOGICAL STUDY
The first case of Acquired Immunodeficiency Syndrome (AIDS) was reported in Africa. But today India is considered as a new hotbed for this disease. AIDS is caused by a retrovirus human immunodeficiency virus (HIV). Two t...
ASSESSMENT OF THE LEVEL OF HEALTH CHECK AWARENESS AMONG STAFF OF DELTA STATE UNIVERSITY, ABRAKA, NIGERIA
Background: Early detection of diseases through health checks could help reduce complications and mortality from chronic diseases. Adopting preventive health behavior is essential for maintaining a productive workforce....
HPTLC- A VERSATILE SEPARATION METHOD
Analysis of pharmaceutical, natural compounds and newer drugs is mandate route used in all the stages of drug discovery and development process. High-performance thin layer chromatography is one of the classy instrumenta...