Activity of the Respiratory Chain Enzymes of Blood Leucocytes’ Mitochondria Under the Conditions of Toxic Hepatitis Induced Against the Background Alimentary Deprivation of Protein
Journal Title: Журнал ÑтреÑÑ-физиологии и биохимии - Year 2015, Vol 11, Issue 4
Abstract
Full functioning of the leucocytes’ energy supply system is one of the essential factors for the immune surveillance system effective work. The pivotal enzymes of the leucocytes’ energy biotransformation system are NADH-ubiquitin reductase, a marker of the Complex I of respiratory chain activity, and succinate dehydrogenase, key enzyme of the Complex II of respiratory chain. The aim of research – to study the NADH-ubiquitin reductase and succinate dehydrogenase activity of the blood leucocytes’ mitochondria under the conditions of toxic hepatitis induced against the background alimentary deprivation of protein. It is shown, that under the conditions of acetaminophen-induced hepatitis a reduction of the NADH-ubiquitin reductase enzymatic activity is observed on the background activation of the succinate-dependent way of the mitochondrial oxidation. Conclusion was made that alimentary deprivation or protein is a factor, aggravating the misbalance of the energy biotransformation system in the leucocytes of rats with toxic hepatitis. Established activity changes of the leucocytes’ mitochondria respiratory chain key enzymes may be considered as one of the mechanisms, directed on the maintenance of leucocytes energy supply on a level, sufficient for their functioning. Research results may be used for the biochemical rationale of the therapeutic approaches to the elimination and correction of the leucocytes’ energy metabolism disturbances consequences under the conditions of acetaminophen-induced hepatitis, aggravated by the alimentary protein deprivation.
Authors and Affiliations
O. Voloshchuk, G. Kopylchuk
Keywords
Related Articles
- EP ID EP159116
- DOI -
- Views 113
- Downloads 0
Genetic Analysis for Some of Morphological Traits in Bread Wheat under Drought Stress Condition Using Generations Mean Analysis
Perception of genes action controlling of quantitative traits is very important in genetic breeding methods the plant populations. to study and estimate the parameters of genetic and appointment the best genetically mode...
СВЕТОЗАВИСИМЫЕ ИЗМЕНЕНИЯ ГЕНЕРАЦИИ ПЕРОКСИДА ВОДОРОДА И АКТИВНОСТИ ПЕРОКСИДАЗ ПРОРОСТКОВ ПШЕНИЦЫ
Выявлено участие света в модификации активности пероксидазной ферментной системы внутриклеточного компартмента побегов и корней проростков пшеницы и генерации пероксида водорода. Показано, что в надземных частях проростк...
24-Epibrassinolide Mediated Changes in Photosynthetic pigments and Antioxidative Defence System of Radish Seedlings under Cadmium and Mercury Stress
The present work was conducted to study the effects of 24-EBL on photosynthetic pigments (total chlorophyll, chl a, chl b, carotenoid, anthocyanin and flavonoid content) and activities of antioxidative enzymes (guaiacol...
Biocrystallomics Methods in Estimation of the Action of Different Stress Factors
[b]Background:[/b] it is well-known that in critical conditions the general response on stimulation is common adaptation syndrome, which includes the mobilization of organism reserves and restructuring of homeostatic mec...
Effect of salt stress on expression of carotenoid pathway genes in tomato
Carotenoids, the naturally occurring isoprenoids form essential components of photosynthetic antenna and reaction centre complexes. Thus they play a significant role in absorption, dissipation and transfer of light energ...