Acute Myeloid Leukemia: analysis of epidemiological profile and survival rate
Journal Title: Jornal de Pediatria - Year 2016, Vol 92, Issue 3
Abstract
Objective To describe the epidemiological profile and the survival rate of patients with acute myeloid leukemia (AML) in a state reference pediatric hospital. Method Clinical–epidemiological, observational, retrospective, descriptive study. The study included new cases of patients with AML, diagnosed between 2004 and 2012, younger than 15 years. Results Of the 51 patients studied, 84% were white; 45% were females and 55%, males. Regarding age, 8% were younger than 1 year, 47% were aged between 1 and 10 years, and 45% were older than 10 years. The main signs/symptoms were fever (41.1%), asthenia/lack of appetite (35.2%), and hemorrhagic manifestations (27.4%). The most affected extra-medullary site was the central nervous system (14%). In 47% of patients, the white blood cell (WBC) count was below 10,000/mm3 at diagnosis. The minimal residual disease (MRD) was less than 0.1%, on the 15th day of treatment in 16% of the sample. Medullary relapse occurred in 14% of cases. When comparing the bone marrow MRD with the vital status, it was observed that 71.42% of the patients with type M3 AML were alive, as were 54.05% of those with non-M3 AML. The death rate was 43% and the main proximate cause was septic shock (63.6%). Conclusions In this study, the majority of patients were male, white, and older than 1 year. Most patients with WBC count <10,000/mm3 at diagnosis lived. Overall survival was higher in patients with MRD <0.1%. The prognosis was better in patients with AML-M3.
Authors and Affiliations
Mariana de Lima
Keywords
Related Articles
- EP ID EP523473
- DOI 10.1016/j.jped.2015.08.008
- Views 54
- Downloads 0
The road to eliminate mother-to-child HIV transmission
The World Health Organization's Global Health Observatory estimates that 78 million people have been infected with the human immunodeficiency virus (HIV) during the course of the epidemic, and that 39 million men, women,...
Comparison of two maintenance electrolyte solutions in children in the postoperative appendectomy period: a randomized, controlled trial
Objective To compare two electrolyte maintenance solutions in the postoperative period in children undergoing appendectomy, in relation to the occurrence of hyponatremia and water retention. Methods A randomized clinica...
Effect of maternal supplementation with vitamin E on the concentration of α-tocopherol in colostrum
Objective To evaluate the effect of maternal supplementation with vitamin E on the concentration of α-tocopherol in colostrum and its supply to the newborn. Method This randomized clinical trial enrolled 99 healthy adul...
Protective effects of human milk antimicrobial peptides against bacterial infection
Breast-feeding provides the nursing infant with a plethora of molecules evolved to optimally develop the infant's tissues and organs. Human milk contains numerous bioactive molecules that modulate the immune system as we...
Validation of a subjective global assessment questionnaire
Objective To validate the Subjective Global Nutritional Assessment (SGNA) questionnaire for Brazilian children and adolescents. Methods A cross-sectional study with 242 patients, aged 30 days to 13 years, treated in ped...