Acute Oral Toxicity of Hydrofluoric Acid Controlled with Gq-300® Additive Fixed Dose Procedure-Acute Oral Toxicity -Ocde420
Journal Title: Advances in Clinical Toxicology - Year 2019, Vol 4, Issue 2
Abstract
This paper demonstrates the tolerable acute oral toxicity of a solution composed of Hydrofluoric acid (HF) at 24% concentration and GQ-300® as a controlling additive. The literature describes pure HF as a liquid, corrosive, colorless, fuming, (identifying CAS number 7664-39-3). GQ-300®, additive consisting of a strongly acidic chemical composition and safe for human use, obtained by the mixing of strong acids with the aim of achieving a balanced mixture of acids which allows, by means of additivation, the control and safe handling of other strong and corrosive acids commonly used in water treatment, cleaning of scale of silicates, in sites with contents of silicates to enhance recovery of metal, non-metal mining and hydrocarbon such as oil and gas. Since there is no precise information about the toxicity of this mixture, or it is expected that the test material is toxic, the study of oral toxicity uses varying volumes of fixed oral doses of three solutions of different concentrations of HF Controlled with the GQ - 300® additive Administered in rats in order to know the tolerable acute toxicity of the mixture. Obtaining as a result that the HF mixture controlled with GQ-300®, administered to rats wistar by mouth in a volume of 20 µl with a range of 275 to 289 mg/kg, have a tolerable dose of acute toxicity greater than the pure HF to 48% , which means that this GQ controller minimizes the toxic action of the HF.
Authors and Affiliations
Yasmin-Morales*, Yepsys-Montero, Andres-Osorio, Lewis Pozo, David Martucci and William Jimenez
Keywords
Related Articles
- EP ID EP751654
- DOI 10.23880/act-16000152
- Views 20
- Downloads 0
Mechanism of Action of Nerve Growth Factor Induced Histamine Release from Mast Cells during the Inflammation Process
Mast cells and the biogenic amine, histamine, play a central role in inflammatory reactions. Nerve growth factor (NGF) is essetial for the survival of neurones and has significant role in inflammation and repair of tissu...
The Level of Lead (Pb) among Students in Qatar Schools and its Relationship to Academic Achievement and Violent Behavior
Introduction: Lead (Pb) has no any known biological or physiological function in the body. Its accumulation has been associated with various damaging effects, particularly in the nervous system. Study objectives: to me...
Arctic Resilience: Fire, Food, Contaminant, and Education Nexus along the Yukon River Watershed
River watersheds are among the most complex terrestrial features in Alaska, performing valuable ecosystem functions and providing services for human society. Rivers are vital to both estuarine and aquatic biota and play...
Environmental Justice, Toxicology and Politics
The Earth and all its inhabitants, including humans, regardless of color, race, income level, or nationality, should be treated with respect as to the implementation and / or enforcement of environmental policies, laws o...
Radiation/Drug Interactions and the Combinational Effects of Tyrosine Kinase Inhibitors and Radiation Therapy in the Treatment of Cancer
Introduction: Progress in both the development of Tyrosine Kinase Inhibitors (TKIs) and modern radiation therapy (RT) have opened new horizons for the safe and effective treatments of cancer. Combination therapies of TKI...