Acute toxicity of the imidacloprid in quails
Journal Title: Бюлетень "Ветеринарна біотехнологія" - Year 2017, Vol 30, Issue
Abstract
Introduction. Results of the determination of acute toxicity for classification of substances, which is expressed in median lethal dose index (LD50) that defines statistically significant dose of a substance which causes death of 50% of the animals in the experimental group are presented in the article. The goal of the work. The aim of our work was to determine the acute oral toxicity of imidacloprid in quail’s model. Materials and methods. Range of doses was defined in the preliminary experiment. 4 test groups were administered imidacloprid as aqueous emulsion in doses 2, 20, 200 and 2000 mg/kg of body weight. In the second experiment 6 groups of quails were formed for preparation application in doses 5, 10, 20, 40, 60 and 80 mg/kg of body weight. Also, two control groups were formed. Each group had 7 quail (n = 7). Results of research and discussion. Acute poisoning of quails with imidacloprid showed the following clinical symptoms: depression, lack of appetite, decreased reaction to external stimuli. The death of the birds observed during the first two hours after administration of imidacloprid. Pathologic signs of acute poisoning characterized by increase in atrial and liver size, vessels of the internal organs were filled with blood; crop the yellow-green fodder masswere found in gizzard probably due to a significant biliation.Conclusions and prospects for further research. It has been determined, that the LD50 value of imidacloprid after single oral treatment in male quail is 32,53 ± 6,97 mg/kg of body weight, which can be attributed to highly toxic substances (1st class of danger) in accordance with hygienic classification of pesticides by Medved L.I. (1987) and DSP 8.8.1.2.002-98 to. Determination of toxicokinetic and toxicodynamic parameters of imidacloprid for quail will be next stage of our research.
Authors and Affiliations
Roman Dotsenko
Keywords
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- EP ID EP267277
- DOI 10.31073/vet_biotech30-07
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