Additive interaction of levetiracetam with lamotrigine in the mouse 6 Hz psychomotor seizure model – an isobolographic analysis

Journal Title: Current Issues in Pharmacy and Medical Sciences - Year 2013, Vol 26, Issue 1

Abstract

The aim of this study was to characterize the anticonvulsant effects of levetiracetam (LEV) in combination with lamotrigine (LTG – a second-generation antiepileptic drug), in the mouse 6 Hz psychomotor seizure model. Limbic (psychomotor) seizure activity was evoked in albino Swiss mice by a current (32 mA, 6 Hz, 3 s stimulus duration) delivered via ocular electrodes and isobolographic analysis for parallel dose-response relationship curves (DRRCs) was used to characterize the consequent anticonvulsant interactions between the drug combinations. Results indicated that LEV administered singly was associated with a DRRC that was parallel to that for LTG. With isobolography for parallel DRRCs, the combination of LEV with LTG at three fixed-ratios of 1:3, 1:1 and 3:1 exerted additive interaction. LEV combined with LTG exerted additive interaction in the mouse 6 Hz psychomotor seizure model.

Authors and Affiliations

Jarogniew Łuszczki, Aleksandra Wlaź, Ewa Marzęda, Dariusz Durmowicz, Magdalena Florek-Łuszczki

Keywords

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  • EP ID EP100401
  • DOI -
  • Views 116
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How To Cite

Jarogniew Łuszczki, Aleksandra Wlaź, Ewa Marzęda, Dariusz Durmowicz, Magdalena Florek-Łuszczki (2013). Additive interaction of levetiracetam with lamotrigine in the mouse 6 Hz psychomotor seizure model – an isobolographic analysis. Current Issues in Pharmacy and Medical Sciences, 26(1), 82-87. https://europub.co.uk./articles/-A-100401