Adipose Tissue-Derived Mesenchymal Stem Cells: A Novel Therapy in Orthopedics
Journal Title: Journal of Orthopedics & Rheumatology - Year 2018, Vol 5, Issue 1
Abstract
Background: Mesenchymal stem cells can differentiate into a variety of cell types. They have the ability to release bioactive molecules, making them attractive tools in cell-based therapies. Adipose tissue is an ideal source of autologous mesenchymal stem cells for its abundance and easy access. Mesenchymal stem cells are routinely obtained enzymatically from lipoaspirate as stromal vascular fraction. Objectives: The aim of this review is to investigate the advantages of adipose derived stem cells in orthopedic application. Methods: Randomised controlled trials (RCTs) and non-RCTs, in addition to cohort and case control studies, as well as case series were included. Search language was restricted to English and time starting from year 2012. Only published papers were eligible. Results: Thirteen articles were included in the review, they consisted of 1 RCT, 4 nRCTs, 1 prospective comparative study, 1 longitudinal cohort study, 2 case control studies, 3 case series and one case report. The number of patients injected with stem cells ranged between 12 and 1128. A total of 1482 patients were treated with adipose derived stem cells. Conclusion: The use of adipose derived stem cells had shown to be safe and effective in bone and cartilage repair.
Authors and Affiliations
Ahmad Salah Naja
Keywords
Related Articles
- EP ID EP488192
- DOI 10.13188/2334-2846.1000038
- Views 85
- Downloads 0
Massive Abdominal Lymphadenopathy as a Manifestation of Connective Tissue Diseases. Report of Two Cases and Review of the Literature
In this report, massive abdominal lymphadenopathy of the reactive type, related to the underlying disease activity, was described in a patient with systemic lupus erythematosus and another one with mixed connective tissu...
Ex-vivo Evaluation of 99mTc Labeled Glucosamine Sulfate(99mTcGS) in Articular Cartilage. Relevance for Osteoarthritis Imaging
Background: Glucosamine sulfate (GS) is widely used in the treatment of osteoarthritis, but no data concerning the local uptake of GS in articular cartilage exist. For this reason we performed radiolabeling of GS (Rottap...
Yoga as a treatment for chronic low back pain: A systematic review of the literature
Objectives: Chronic low back pain (CLBP) affects millions of people worldwide, and appears to be increasing in prevalence. It is associated not only with pain, but also with increased disability, psychological symptoms,...
Avulsion of Deep MCL at the Proximal Attachment to the Medial Femoral Condyle
The medial collateral ligament (MCL) is the most commonly injured ligament of the knee joint. Proximal superficial medial collateral ligament (MCL) tears occur more frequently than do distal ones. Isolated avulsion of de...
Challenges Faced During Primary Total Knee Arthroplasty in Rheumatoid Knee in Females in the 5th Decade with Severe Osteoporosis
Introduction: Rheumatoid Arthritis [RA] is a chronic inflammatory disorder of the synovium resulting in joint destruction. The knee is among the most commonly affected joints in RA and advanced arthritis of the involved...