Adropin levels of biological fluids decrease in patients with proteinuria
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2015, Vol 3, Issue 8
Abstract
Proteinuria can be caused, primarily by glomerular diseases or, secondarily by systemic disorders such as diabetes (DM). Adropin (ADR) is a peptide hormone that has been shown to regulate energy homeostasis by moderating glucose- mediated insulin release. The aim of this study was to measure ADR levels in blood and saliva samples taken from proteinuric patients, with and without diabetes, in whom energy homeostasis seriously differs. Samples were taken from 28 diabetic proteinuria patients, 26 non- diabetic proteinuria patients, and 26 healthy control subjects. Plasma and saliva ADR levels were measured using an ELISA kit according to the manufacturer's instructions. Statistical analysis was performed using SPSS 12 (SPSS Inc., Chicago, IL, USA). Groups were compared using the Kruskal-Wallis test, and then a Mann-Whitney post hoc test was performed. The Pearson test was used for correlation analysis. The plasma and saliva ADR levels of the non- diabetic and control groups were higher than those of the diabetic group. ADR levels of control group were also higher than non- diabetic group. There was a negative correlation between plasma adropin and urea, HbA1c levels. In this study, plasma and saliva ADR levels from the diabetic group were lower than both the non-diabetic and control groups. ADR can be a cornerstone in respect to our study, because, in states with excess proteinuria, the liver generates too many lipid products and energy homeostasis deteriorates, especially in diabetic subjects. Keywords: Proteinuria, diabetic nephropathy, adropin
Authors and Affiliations
Ali Gürel, Hasan Atlı, Deccane Düzenci, Süleyman Aydın, Ayhan Doğukan
Keywords
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