Adsorptive-Rheological Properties of Blood Serum in Gouty Nephropathy
Journal Title: Нирки - Year 2014, Vol 3, Issue 9
Abstract
The aim and tasks of the study — to evaluate clinical-pathogenetic significance of changes in adsorptive rheological properties of blood serum (ARPB) in patients with different clinical courses of gouty nephropathy. Material and methods. With the help of interfacial tensiorheometry of blood there have been examined 89 patients and 30 apparently healthy people of control group (mainly males). We have used computer devices MPT2-Lauda, ADSA-Toronto and PAT2-Sinterface. Urolithic type of nephropathy has been diagnosed in 39 % of cases, latent one — in 61 %. Reduced kidney function was in 54 % of the examined patients. Results and their discussion. Type of gouty nephropathy has an significant impact on the integral parameters of urine determining the levels of proteinuria, leukocyturia, oxalaturia, uricuria, fibronectinuria, b2-microglobulinuria and nitrituria, clearance of creatinine, uric acid, oxypurinol and calcium, and urolithic type of kidney lesion is evident with higher, in comparison with latent type, surface tension of blood serum that is connected with parameters of kidneys function, has prognostic significance, influences the interfacial surface activity and viscoelastic urine properties. Conclusions. ARPB changes reflect the character of gouty nephropathy course, single indices take part in pathogenesis of the disease and might have prognostic significance.
Authors and Affiliations
O. V. Sinyachenko, Yu. O. Bryzhataya, P. O. Sinyachenko
Keywords
Related Articles
- EP ID EP225246
- DOI -
- Views 102
- Downloads 0
Uric Acid and its Role in the Progression of Chronic Kidney Disease: Do We Know Enough?
At the present stage of medical science development, the role of hyperuricemia as the factor of chronic kidney disease progression is actively discussed. Some epidemiological studies have been presented to evaluate the r...
National Guidelines «Acute Kidney Injury: Basic Principles of the Diagnosis, Prevention and Treatment (2015)» Part II
The main problems of acute kidney injury (AKI) are considered. The necessity of introduction of the AKI concept into the practice of national health care is justified. Specific recommendations for the diagnosis, monitori...
Main Nutritional Lithogenic Factors in Diets of Polish Patients with Kidney Stones
Background. Nutrition is one of the most important determinants of kidney stone formation. This study was designed to evaluate lithogenic factors in diet of patients with renal calculi. Materials and methods. 40 stone-f...
CAKUT-Syndrome and Chronic Kidney Disease: the Concept of Nephrology Approach
This article presents the results of the analysis of the etiological structure of chronic kidney disease (CKD) in Kyiv children from 2006 to 2015. In the structure of CKD, CAKUT-syndrome dominates — from 62.3 % (2013) to...
Moxonidine in the treatment of chronic kidney disease associated with hypertension
Kidney disease pathogenesis is closely related to essential or secondary hypertension. Treatment of chronic kidney disease associated with hypertension requires a comprehensive causal and pathogenetic therapy. The topic...