ADVANCE ASPECTS OF SEPSIS: AN OVERVIEW
Journal Title: International Journal of Research in Pharmacy and Science - Year 2013, Vol 3, Issue 2
Abstract
It is defined as the generalized inflammatory response elicited by an infectious process. Systemic inflammatory response syndrome(SIRS) is defined as the presence of two or more of the following: (1) temperature greater than 38°C (100.4°F) or less than 36°C (96.8°F); (2) pulse rate greater than 90 beats/min; (3) respiratory rate greater than 20 breaths/min (4) Partial pressure of carbon dioxide (PCO2) < 32 mm and (5) WBC count greater than 12,000/mm3 or less than 4,000/mm3, or greater than 10% immature band forms. Severe sepsis is manifested by organ dysfunction (i.e. hypo perfusion, tissue hypoxia, lung injury, etc.), while septic shock is a type of severe sepsis marked by hypotension despite fluid resuscitation. Sepsis frequently occurs after hemorrhage, trauma, burn or abdominal surgery. The outcome of sepsis and septic shock has not significantly improved in recent decades despite the development of numerous drugs and supportive care therapies. To reduce sepsis-related mortality, a better understanding of molecular mechanism(s) associated with the development of sepsis and sepsis-related organ injury is essential. There is increasing evidence that Toll-like receptors (TLRs) play a key role in the mediation of systemic responses to invading pathogens during sepsis. However, the role of TLRs in the development of sepsis and in sepsis-related organ injury remains debatable.
Authors and Affiliations
Rupanshi Sharma, Vaishali Mangal
Keywords
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