Advances in anti-inflammatory and immunoregulatory mechanisms of sinomenine
Journal Title: Traditional Medicine Research - Year 2021, Vol 6, Issue 1
Abstract
Sinomenine, a major active ingredient from traditional Chinese medicine Qingfengteng (Sinomenium acutum (Thunb.) Rehd.et Wils.), has been proven to have anti-inflammatory, analgesic, anti-tumor, immunomodulatory and other pharmacological effects, and is clinically used for various inflammatory and autoimmune diseases. However, due to complex molecular mechanisms and pathological characteristics in inflammatory and immune responses, the precise anti-inflammatory and immunological mechanisms of sinomenine are still unclear. This review summarizes the anti-inflammatory and immunoregulatory mechanisms of sinomenine during recent years in rheumatoid arthritis, respiratory system, nervous system, digestive system and organ transplant rejection. The molecular pharmacological mechanisms of sinomenine responsible for anti-inflammatory and immunosuppressive effects were in detail introduced based on 3 aspects including cytokines induction, signal pathways modulation and immune cells function regulation. Moreover, this review also raises some concerns and challenges in future sinomenine study, which will contribute to crucial theoretical and practical significance for in-depth development and utilization of sinomenine as medicinal resource.
Authors and Affiliations
Xiao-Qing Zhou,Ke-Wu Zeng
Keywords
Related Articles
- EP ID EP690509
- DOI 10.12032/TMR20200814194
- Views 278
- Downloads 0
International expert consensus on clinical application of traditional Chinese medicine formula granules
Guided by the theory of traditional Chinese medicine (TCM), TCM formula granules are made through the optimal process of extraction, concentration, drying, and granulation by combining modern new preparation technologies...
Efficacy and safety of traditional Chinese medicine kidney-nourishing formula for Alzheimer's disease in comparison with donepezil: a systematic review and meta-analysis
Objective: Finding an effective therapy against Alzheimer’s disease (AD) has been associate increasingly pressing issue and traditional Chinese medicine (TCM) is widespread in the prevention and treatment of AD in China....
Effects of herbal medicine in gastroesophageal reflux disease symptoms: a systematic review and meta-analysis
Background: Pyrosis and regurgitation are the cardinal symptoms of gastroesophageal reflux disease. Several herbs have been used for treating gastrointestinal disorders worldwide. This systematic review was conducted to...
Jian-Gan-Xiao-Zhi decoction ameliorates high-fat high-carbohydrate diet-induced non-alcoholic fatty liver disease and insulin resistance by regulating the AMPK/JNK pathway
Background: Non-alcoholic fatty liver disease (NAFLD) can cause insulin resistance (IR) and diabetes. Our previous studies have demonstrated that Jian-Gan-Xiao-Zhi decoction (JGXZ) could be effective for the treatment of...
Molecular docking study on the molecular mechanism of rhaponticin for treatment of chronic myelocytic leukemia
Molecular docking can not only design drugs for the targets, but also detect mechanism of drug effecting on the targets. This study researched the interaction of rhaponticin and genes associated with chronic myelocytic l...